Radiation Dose and Fractionation for Limited-stage Small-cell Lung Cancer: Survey of US Radiation Oncologists on Practice Patterns

Clinical Lung Cancer
Matthew Joseph FarrellTimur Mitin

Abstract

Thoracic radiotherapy (TRT) with concurrent chemotherapy is standard for limited-stage small-cell lung cancer (LS-SCLC). However, the optimal dosing and fractionation remain unclear. The National Comprehensive Cancer Network guidelines have recommended either 45 Gy delivered twice daily (BID) or 60 to 70 Gy delivered once daily (QD). However, the current practice patterns among US radiation oncologists are unknown. We surveyed US radiation oncologists using an institutional review board-approved questionnaire. The questions covered demographic data, self-rated knowledge of key trials, and treatment recommendations. We received 309 responses from radiation oncologists. Of the 309 radiation oncologists, 60% preferred TRT QD and 76% acknowledged QD to be more common in their practice. The respondents in academic settings were more likely to endorse BID treatment by both preference (P = .001) and actual practice (P = .009). The concordance between preferring QD and administering QD in practice was 100%. In contrast, 40% of respondents who preferred BID actually administered QD more often. Also, 15% of physicians would be unwilling to switch from QD to BID and 3% would be unwilling to switch from BID to QD, even on patient request. ...Continue Reading

Citations

Feb 9, 2021·World Journal of Clinical Oncology·José Máximo BarrosFelipe Couñago
Sep 15, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Antonin LevyUNKNOWN EORTC Lung Cancer Group (EORTC LCG)
Apr 25, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jeffrey A BogartEverett E Vokes
May 25, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Markus GlatzerPaul M Putora
Aug 23, 2021·Clinical Lung Cancer·Olsi GjyshiChad G Rusthoven
Jan 6, 2022·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A BogartMichael D Mix

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