Radiation dose-response relationships for thyroid nodules and autoimmune thyroid diseases in Hiroshima and Nagasaki atomic bomb survivors 55-58 years after radiation exposure

JAMA : the Journal of the American Medical Association
Misa ImaizumiKatsumi Eguchi

Abstract

Effects of irradiation on thyroid diseases such as thyroid nodules and autoimmune thyroid diseases have not been evaluated among people exposed to radiation more than 50 years in the past. To evaluate the prevalence of thyroid diseases and their radiation-dose responses in atomic bomb survivors. Survey study comprising 4091 cohort members (mean age, 70 [SD, 9] years; 1352 men and 2739 women) who participated in the thyroid study at the Radiation Effects Research Foundation. Thyroid examinations were conducted between March 2000 and February 2003. Prevalence of thyroid diseases, including thyroid nodules (malignant and benign) and autoimmune thyroid diseases, and the dose-response relationship of atomic bomb radiation in each thyroid disease. Thyroid diseases were identified in 1833 (44.8%) of the total participants (436 men [32.2% of men] and 1397 women [51.0% of women]) (P<.001). In 3185 participants, excluding persons exposed in utero, not in the city at the time of the atomic bombings, or with unknown radiation dose, the prevalence of all solid nodules, malignant tumors, benign nodules, and cysts was 14.6%, 2.2%, 4.9%, and 7.7%, respectively. The prevalence of positive thyroid antibodies, antithyroid antibody-positive hypoth...Continue Reading

Citations

Mar 21, 2013·European Journal of Endocrinology·Ji Min HanWon Bae Kim
Jan 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fang WangYan-Gang Wang
Nov 28, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Long YuJianming Cai
May 22, 2013·Journal of Thyroid Research·Francis S BalucanTerry F Davies
Jun 21, 2014·Endocrine-related Cancer·M A MarcelloL S Ward
May 9, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yulan YanXi Qin
May 15, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jenny K HoangStephen Farrell
Jun 10, 2008·Physics in Medicine and Biology·X George XuHarald Paganetti
Oct 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Kiyohiro HamataniYoichiro Kusunoki
Jul 1, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Adel AssaadJennifer L Hunt
Feb 27, 2010·Endocrine Pathology·Elias SozopoulosSofia Tseleni-Balafouta
Aug 30, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Dusica ZivanovićJelena Milasin
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Fabrizio Guarneri, Salvatore Benvenga
Nov 28, 2007·Current Treatment Options in Oncology·Dina M Elaraj, Orlo H Clark
Oct 18, 2006·Thyroid : Official Journal of the American Thyroid Association·Stefan KindlerHenry Völzke
Feb 6, 2007·Thyroid : Official Journal of the American Thyroid Association·Sathya SubbiahArthur B Schneider
Oct 25, 2007·Thyroid : Official Journal of the American Thyroid Association·Gregory A BrentR Thomas Zoeller
Jun 3, 2009·Thyroid : Official Journal of the American Thyroid Association·Ohki SaitohYuji Nagayama
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Gregory A Brent
Sep 1, 2011·Thyroid : Official Journal of the American Thyroid Association·Misa ImaizumiMasazumi Akahoshi
Mar 27, 2012·The Medical Clinics of North America·Jaime P Almandoz, Hossein Gharib
Mar 5, 2011·The Lancet Infectious Diseases·Paula BoaventuraManuel Sobrinho-Simões
Jun 12, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nadia HaddyFlorent de Vathaire
May 5, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shiu-Chen JengJason Chia-Hsien Cheng
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Diana S Dean, Hossein Gharib
Sep 3, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Julian R PerksJames A Purdy
Sep 16, 2008·Regulatory Toxicology and Pharmacology : RTP·Chao W Chen
Apr 26, 2007·Journal of Magnetic Resonance Imaging : JMRI·Richard C SemelkaWalter Huda
Nov 30, 2006·Journal of Surgical Oncology·Jennifer E Rosen, Michael D Stone
Aug 1, 2012·International Journal of Cancer. Journal International Du Cancer·Kyoji FurukawaKiyohiko Mabuchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.