Radiation dosimetry for radionuclide therapy in a nonmyeloablative strategy

Cancer Biotherapy & Radiopharmaceuticals
Gerald L DeNardoSally J DeNardo

Abstract

Radionuclide therapy extends the usefulness of radiation from localized disease of multifocal disease by combining radionuclides with disease-seeking drugs, such as antibodies or custom-designed synthetic agents. Like conventional radiotherapy, the effectiveness of targeted radionuclides is ultimately limited by the amount of undesired radiation given to a critical, dose-limiting normal tissue, most often the bone marrow. Because radionuclide therapy relies on biological delivery of radiation, its optimization and characterization are necessarily different than for conventional radiation therapy. However, the principals of radiobiology and of absorbed radiation dose remain important for predicting radiation effects. Fortunately, most radionuclides emit gamma rays that allow the measurement of isotope concentrations in both tumor and normal tissues in the body. By administering a small "test dose" of the intended therapeutic drug, the clinician can predict the radiation dose distribution in the patient. This can serve as a basis to predict therapy effectiveness, optimize drug selection, and select the appropriate drug dose, in order to provide the safest, most effective treatment for each patient. Although treatment planning for...Continue Reading

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Citations

Jun 14, 2003·Cancer Biotherapy & Radiopharmaceuticals·Gerald DeNardoSally DeNardo
Sep 30, 2004·Cancer Biotherapy & Radiopharmaceuticals·Thomas KullGerhard Glatting
Nov 9, 2011·Cancer Biotherapy & Radiopharmaceuticals·Jenny OddstigEva Forssell-Aronsson
Jun 9, 2005·Nuclear Medicine Communications·Hubert M ThierensKlaus Bacher
Jun 9, 2005·Nuclear Medicine Communications·Klaus Bacher, Hubert M Thierens
Mar 15, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jazmin SchwartzJoseph A O'Donoghue
Oct 19, 2006·Nuclear Medicine and Biology·Jenny OddstigEva Forssell-Aronsson
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dietmar BerndorffLudger M Dinkelborg
Dec 14, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexander B StillebroerWim J G Oyen

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