Radiation fabrication of Xanthan-based wound dressing hydrogels embedded ZnO nanoparticles: In vitro evaluation

International Journal of Biological Macromolecules
Amany I RaafatAsmaa M Mohamed

Abstract

Depending on the biocompatibility of Xanthan, polyvinyl alcohol and the antibacterial efficiency of zinc oxide nanoparticles (ZnO), a series of (Xanthan-polyvinyl alcohol)/ZnO nanocomposite hydrogels were prepared as wound dressing using eco-friendliness 60Co γ-ray irradiation facility. ZnO nanoparticles were characterized using X-ray diffraction, UV-vis spectroscopy, transmission electron microscopy and energy dispersive X-ray analysis. The size of ZnO nanoparticles was ranged between 15 and 25 nm. The presence of ZnO nanoparticles reconstructed the internal structure of the hydrogel network which aid in a homogenous porous structure as indicated by scanning electron micrographs. Such adequate porosity along with the presence of ZnO nanoparticles controls the fluid uptake ability, water retention and water vapor transmission rate. The fluid uptake ability in pseudo-extracellular fluid and water ranged between (554-664%) and (1281-1603%), respectively. After exposure to air for 6 h, ZnO dressings kept about 50-65% of their water content which makes them more suitable for moderate exudating wounds. Water vapor transmission rate ranged between 167 and 184 (g/(m2 h) which is sufficient to keep wound's surface moist. ZnO dressings ...Continue Reading

Citations

Jun 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexandra Elena StoicaAlexandru Mihai Grumezescu
Jul 8, 2020·Materials·Alexandra Elena StoicaAlexandru Mihai Grumezescu
Jan 30, 2021·International Journal of Biological Macromolecules·Ling DingJi Zhang
Mar 31, 2021·International Journal of Biological Macromolecules·Jesper T N KnijnenburgKaewta Jetsrisuparb

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