Radiation-induced brachial plexopathy and hypofractionated regimens in adjuvant irradiation of patients with breast cancer--a review

Acta Oncologica
Jacek GałeckiWojciech Załucki

Abstract

In order to increase the availability of adjuvant radiotherapy of breast cancer patients and make it more convenient and cheaper, in numerous cancer centres, the dose per fraction has been increased from 2 Gy to 2.25-2.75 Gy and the total dose has been decreased from 50 Gy to 40-45 Gy. The risk of developing any late complications after conventionally fractionated megavoltage radiotherapy is estimated to be below 1%. The aim of this review is to determine whether hypofractionated regimens increase the risk of damage to the brachial plexus. A review of the published literature shows that the use of doses per fraction in the range from 2.2 Gy to 4.58 Gy with the total doses between 43.5 Gy and 60 Gy causes a significant risk of brachial plexus injury which ranged from 1.7% up to 73%. The risk of radiation induced brachial plexopathy was smaller than 1% using regimens with doses per fraction between 2.2 and 2.5 Gy with the total doses between 34 and 40 Gy. Surgical manipulations in the axilla and chemotherapy have to be taken into account as additional factors which may increase the risk of brachial plexopathy.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S M PierceJ R Harris
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B L FowbleR L Goodman
Nov 1, 1991·Clinical Oncology : a Journal of the Royal College of Radiologists·B MageeR Swindell
Jul 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S PowellC Parsons
Jan 1, 1989·International Journal of Radiation Biology·S M BentzenD O Dixon
Jan 1, 1987·International Journal of Radiation Oncology, Biology, Physics·G DeloucheJ M Kurtz
Jan 1, 1981·Neurology·S H KoriJ B Posner
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·N K OlsenC Rose
Feb 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L E RutqvistH Johansson
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·T Bates, R G Evans
Oct 2, 1997·The New England Journal of Medicine·J RagazI A Olivotto
Mar 30, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H J Dobbs
Sep 15, 2000·Acta Oncologica·S M Bentzen, S Dische
Sep 27, 2000·Clinical Oncology : a Journal of the Royal College of Radiologists·J Brown, D Machin
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·S JohanssonJ Denekamp
Mar 10, 2001·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G Noël, J J Mazeron
Apr 24, 2001·Clinical Oncology : a Journal of the Royal College of Radiologists·J E LivseyR Swindell
Jun 3, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Amira BajrovicWinfried Alberti
Jul 9, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan Van de SteeneGuy Storme
May 10, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·John YarnoldRoger Owen
Apr 2, 1966·British Medical Journal·B A Stoll, J T Andrews

❮ Previous
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Citations

Jan 17, 2009·Physical Therapy·Laura S GilchristKirsten K Ness
Jul 7, 2007·Neurosurgical Focus·John GachianiDavid Kline
Nov 20, 2012·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Subramania Iyer, Deepak Balasubramanian
Apr 29, 2006·Acta Oncologica·Silvia Johansson
Dec 24, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Michael D Stubblefield, Nandita Keole
Jun 5, 2012·International Journal of Radiation Oncology, Biology, Physics·Michael J EblanSmith Apisarnthanarax
Nov 2, 2011·The Breast : Official Journal of the European Society of Mastology·Jonathan D Schoenfeld, Jay R Harris
Nov 9, 2010·Clinical Oncology : a Journal of the Royal College of Radiologists·S ChatterjeeA N Branson
Jun 1, 2010·The Breast : Official Journal of the European Society of Mastology·Caroline L HollowayIvo Olivotto
Jun 29, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·B Henriques de FigueiredoG Kantor
Jul 8, 2010·International Journal of Radiation Oncology, Biology, Physics·Lin KongYouwang Zhang
Dec 9, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hiram A GayBranislav Jeremic
Oct 17, 2008·Critical Reviews in Oncology/hematology·Pelagia G TsoutsouYazid Belkacémi
Apr 15, 2008·The Journal of Hand Surgery·James A Chambers, James N Long
Sep 16, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marc D Piroth
Nov 5, 2014·Muscle & Nerve·Michael D StubblefieldKatarzyna Ibanez
Oct 6, 2015·Advanced Biomedical Research·Shirvan RastegarKeivan Basiri
May 13, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Wilfried BudachUNKNOWN Breast Cancer Expert Panel of German Society of Radiation Oncology (DEGRO)
May 26, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-M Caudrelier, P T Truong
Jan 31, 2012·International Journal of Radiation Oncology, Biology, Physics·Arya AminiJames Welsh
Jul 10, 2010·International Journal of Radiation Oncology, Biology, Physics·Gustavo Arruda VianiSergio Luis Afonso
Jan 21, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shahed N BadiyanFrank A Vicini
Feb 18, 2014·The Breast : Official Journal of the European Society of Mastology·Angel MonteroManel Algara
Dec 8, 2010·Seminars in Radiation Oncology·Valérie ThébergeFrank A Vicini
Sep 12, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P BoisselierY Pointreau
Jan 28, 2017·International Journal of Radiation Oncology, Biology, Physics·Sara BellefqihNoureddine Benjaafar
Oct 31, 2015·British Journal of Pain·Matthew Rd BrownPaul Farquhar-Smith
Jul 24, 2008·Journal of Cancer Survivorship : Research and Practice·Sophie D FossåAlv A Dahl
Mar 19, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M-L Sautter-BihlUNKNOWN Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)
Dec 18, 2013·Der Nervenarzt·C RitterH C Lehmann
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Kurt A Jaeckle
Dec 28, 2019·Journal of Surgical Oncology·Márcia Helena KandaRaphael Leonardo Cunha de Araujo
May 23, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mylin A TorresGary M Freedman
Apr 19, 2007·Acta Oncologica·Bengt Glimelius
May 14, 2016·The American Journal of Nursing·Megan Dunne, Kathleen Keenan
Aug 24, 2017·Muscle & Nerve·Michael Dean Stubblefield
Jan 26, 2021·Advances in Radiation Oncology·Mutlay SayanBruce G Haffty
Jul 14, 2021·CA: a Cancer Journal for Clinicians·Kyle Wang, Joel E Tepper

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