PMID: 11903376Mar 21, 2002Paper

Radiation-induced cancers of the pharynx and larynx: a study of five clinical cases

Clinical Otolaryngology and Allied Sciences
O MalardE Bardet

Abstract

Radiation-induced cancer, a rare clinical entity, is often difficult to diagnose and manage. This study reports a series of five cases of radiocarcinogenesis of the pharynx and/or larynx that developed after external radiotherapy. The primary lesion was diagnosed at a mean age of 50 years (+/-12.9) and the radiation-induced cancer at a mean age of 59 years (+/-13.1), giving a latent period of 9 years (+/-3.7). Analysis of gammagraphic records indicated that four of the patients had developed a secondary tumour in the penumbra of irradiation fields. In these zones, the delivered dose was between 20 and 80% of the prescribed dose, corresponding to an estimated cumulative mean dose of 14.1-56.3 Gy. These results are compared with data in the literature to determine the diagnostic criteria for radiation-induced cancer, possible predisposition (genetic or acquired) and the dose effect.

References

Jan 1, 1979·Cancer·A A TountasP M Leung
Nov 1, 1975·The Annals of Otology, Rhinology, and Laryngology·S Lawson, M Som
Oct 1, 1975·Cancer·W R LeeA L Townsend
Dec 26, 1991·The New England Journal of Medicine·M SwiftC L Chase
Nov 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M Henry-AmarJ M Cosset
Dec 1, 1995·British Journal of Cancer·R Doll
Nov 1, 1995·Radiation and Environmental Biophysics·L SabatierB Dutrillaux
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·J M de MurciaG de Murcia
Jan 15, 1998·Cancer·W G Cahan
Jan 1, 1997·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J M Cosset
Oct 20, 1999·Cancer Genetics and Cytogenetics·L ChauveincB Dutrillaux
May 1, 1948·Cancer·W G CAHAN, H Q WOODARD

❮ Previous
Next ❯

Citations

Aug 22, 2013·The Journal of Laryngology and Otology·O MalardF Espitalier
Aug 16, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Wangyong ZhuQian Tao
Jul 27, 2010·Oral Oncology·Lisa van der PuttenC René Leemans
Sep 15, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Erlend RennemoMorten Boysen
Feb 10, 2009·The British Journal of Oral & Maxillofacial Surgery·E LerouxelO Malard
Nov 10, 2004·Clinical Otolaryngology and Allied Sciences·P A NixN D Stafford
Apr 29, 2004·Clinical Otolaryngology and Allied Sciences·P A NixN Stafford
Feb 19, 2008·Oral Oncology·Remco de BreeC René Leemans
Nov 14, 2020·Advances in Therapy·Andrés Coca-PelazAlfio Ferlito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cellular Biochemistry
Hong LaiShenghan Lai
Clinical Otolaryngology and Allied Sciences
J GreenmanN D Stafford
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
John P LeonettiBrian Herr
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
J CarlO Greisen
© 2022 Meta ULC. All rights reserved