Radiation-induced changes in peripheral nerve by stereotactic radiosurgery: a study on the sciatic nerve of rabbit.

Journal of Neuro-oncology
Zhixiong LinLonghua Chen

Abstract

A large fractional dose in radiotherapy produces better radiobiological results, but there is always a concern of radiation-induced damage to the normal tissues, especially peripheral nerves. This study was to evaluate the radiation-induced changes of sciatic nerve treated by stereotactic radiosurgery (SRS) in rabbit. A localization test was performed on 3 rabbits to determine the reference landmarks to the location of the sciatic nerve of rabbit in CT. Another 12 rabbits were irradiated by a dose of 25 Gy at the sciatic nerve using SRS with 5 non-coplanar arcs. The rabbits were randomized into 3 groups and euthanised at 3, 5, and 7 months after radiotherapy, respectively. Apart from the sensory and motor tests performed on the rabbits, segments of the sciatic nerve were prepared for hematoxylin and eosin staining. Histologic and ultra-structural examinations including morphometric analyses were conducted and compared with the control (non-irradiated side). Apart from the loosening of myelin layers at 5 months, no prominent changes were shown at 3 and 5 months after irradiation. At 7 months, despite the fact that the sensation and motor function tests remained intact, ultra-structural examination showed obvious vacuolation, deg...Continue Reading

References

Apr 1, 1991·International Journal of Radiation Oncology, Biology, Physics·T J KinsellaW F Sindelar
Jul 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E G ShawK C Podratz
Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R A LeCouteurJ T Ingram
Mar 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J WondergemJ D Van Dijk
Sep 1, 1985·International Journal of Radiation Oncology, Biology, Physics·T J KinsellaJ F Harwell
Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·P A JohnstoneW F Sindelar
Jul 1, 1995·International Journal of Radiation Biology·Z VujaskovicT A Colacchio
Jan 1, 1993·International Journal of Radiation Biology·H H de VrindJ Haveman
Feb 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Z VujaskovicT A Colacchio
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·Z VujaskovicT A Colacchio
May 1, 2004·Science·C Norman ColemanTerry C Pellmar
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Toshihiko IuchiKatsunobu Osato
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Dirk RadesJuergen Dunst
May 3, 2007·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Todd PawlickiGary Luxton
Sep 1, 2007·Neurosurgery·Yoshiya YamadaMark H Bilsky
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Yoshiya YamadaZvi Fuks
May 21, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jeffrey A ForquerPeter A S Johnstone
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter S RoseEric Lis

❮ Previous
Next ❯

Citations

Oct 2, 2012·International Journal of Radiation Biology·Savas AktasMehmet Ali Sungur
Feb 1, 2014·Journal of Plastic Surgery and Hand Surgery·Yukako OkuharaMitsuo Ochi
Nov 11, 2020·International Journal of Radiation Oncology, Biology, Physics·Brian Hrycushko, Paul M Medin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Plastic and Reconstructive Surgery
Cynthia M GoodmanGregory R D Evans
Kaibogaku zasshi. Journal of anatomy
S Mizoguchi, M Kikui
The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Simon S LoKathryn E Dusenbery
© 2021 Meta ULC. All rights reserved