PMID: 6975251Oct 1, 1981Paper

Radiation-induced changes of liposomes and lecithin in non-aqueous media

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
T NakazawaT Sakuria

Abstract

Radiation-induced changes of lipids in non-aqueous media were studied to elucidate the process of radiation damage in biological membranes. The lipid peroxidation progressed linearly with increasing dose and decreasing dose rate of gamma-irradiation in soyabean lecithin in chloroform. The fatty acid composition of lecithin also changed, especially in linoleic and linolenic acids. Lower dose rate radiation enhanced these changes in oxic condition. Lipid peroxidation was also shown in lipids extracted from irradiated liposomes or in liposomes prepared from irradiated lecithin in chloroform. The dose-dependent glucose efflux was seen in liposomes prepared from irradiated lecithin in chloroform. These results indicate that the peroxidation of lipid molecules might cause radiation damage to the membrane conformation.

References

May 21, 1976·Biochimica Et Biophysica Acta·A Petkau, W S Chelack
Jan 18, 1974·Science·C A RielyM Lieberman
Sep 8, 1970·Biochimica Et Biophysica Acta·R A Klein
Jun 11, 1968·Biochimica Et Biophysica Acta·J de GierL L van Deenen
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Jan 25, 1984·Biochimica Et Biophysica Acta·T NakazawaO Yukawa
Jan 1, 1988·Free Radical Biology & Medicine·S N Chatterjee, S Agarwal

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