Radiation Induced DNA Double-Strand Breaks in Radiology

RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Michael A KuefnerMichael Uder

Abstract

Shortly after the discovery of X-rays, their damaging effect on biological tissues was observed. The determination of radiation exposure in diagnostic and interventional radiology is usually based on physical measurements or mathematical algorithms with standardized dose simulations. γ-H2AX immunofluorescence microscopy is a reliable and sensitive method for the quantification of radiation induced DNA double-strand breaks (DSB) in blood lymphocytes. The detectable amount of these DNA damages correlates well with the dose received. However, the biological radiation damage depends not only on dose but also on other individual factors like radiation sensitivity and DNA repair capacity. Iodinated contrast agents can enhance the x-ray induced DNA damage level. After their induction DSB are quickly repaired. A protective effect of antioxidants has been postulated in experimental studies. This review explains the prinicple of the γ-H2AX technique and provides an overview on studies evaluating DSB in radiologic examinations. Radiologic examinations including CT and angiography induce DNA double-strand breaks. Even after mammography a slight but significant increase is detectable in peripheral blood lymphocytes. The number of radiation ...Continue Reading

Citations

Aug 9, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Andrej HariAnnalisa Berzigotti
Nov 11, 2017·Journal of Translational Medicine·Tyler A SmithDevendra K Agrawal
Nov 12, 2019·Radiation Protection Dosimetry·Zuzana ŠinkorováAleš Tichý
Oct 31, 2019·Radiation Protection Dosimetry·Lenka JánošíkováDušan Šalát
May 5, 2018·La Radiologia medica·Sergio SalernoPaolo Tomà
Jul 23, 2019·Radiation Protection Dosimetry·Ahmad MohammadbeigiMohammad Taghi Eivazi
Dec 19, 2020·Radiation Protection Dosimetry·Atefeh TahmasebzadehReza Reiazi
Feb 27, 2021·International Journal of Biological Macromolecules·Pankaj Kumar ChaturvediWoo-Yoon Park
Jun 5, 2021·Mutation Research. Reviews in Mutation Research·Venkateswarlu RaaviSolomon F D Paul
Jun 16, 2021·International Journal of Radiation Biology·Marjan BoermaJacqueline P Williams
Aug 10, 2021·Frontiers in Public Health·Martha HabibiGeorgia I Terzoudi

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