Radiation-induced hypothyroidism in patients with breast cancer: a retrospective analysis of 243 cases

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
Gul KanyilmazLütfi Saltuk Demir

Abstract

This study aims to estimate the incidence of hypothyroidism (HT) and to evaluate the predictors affecting the development of HT after radiotherapy (RT) for breast cancer, with a focus on radiation dose-volumetric parameters. Between 2009 and 2015, 243 patients undergoing RT for breast cancer were retrospectively analyzed. Free triiodothyronine (FT3), free thyroxin (FT4), and thyrotropin (TSH) were monitored before and after RT. The relation between the doses to thyroid gland (Dmean, Dmax, Dmin), percentage of thyroid volume receiving > 10 Gy, 20 Gy, 30 Gy, 40 Gy, and 50 Gy (V10 to V50), absolute thyroid volume, and HT were analyzed. The risk of HT according to radiation fields and the other clinic factors were also evaluated. The median follow-up was 41 (range; 6 to 130) months. Sixty-seven percent of the patients received RT to the breast/chest wall and ipsilateral supraclavicular fossa. Of 243 patients, 51 (21%) were diagnosed with HT. The median time to the onset of HT was 27 (range; 5 to 64) months. There were no significant relationships observed between Dmin or V10 to V50 and HT. The surgery type, clinical stage, nodal status, RT field, Dmean, and Dmax were statistically significant predictors for HT in univariate analysi...Continue Reading

Citations

Jun 25, 2019·Journal of Applied Clinical Medical Physics·Emel HaciislamogluAdnan Yoney
Jul 8, 2019·Cancer Causes & Control : CCC·Huah Shin NgMary L McBride
Sep 15, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Huakang HuangAlexander Stessin
Oct 9, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M RogéS Rivera
Jan 8, 2021·International Journal of Radiation Oncology, Biology, Physics·Seo Hee ChoiYong Bae Kim
Oct 15, 2020·Breast Cancer Research : BCR·Anne Mette Falstie-JensenDeirdre P Cronin-Fenton
Jul 14, 2021·International Journal of Cancer. Journal International Du Cancer·Anna JansanaUNKNOWN SURBCAN Group

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