Radiation-induced Oral Mucositis in Brazilian Patients: Prevalence and Associated Factors

In Vivo
Igor Figueiredo PereiraVagner Rodrigues Santos

Abstract

Aim: To determine the prevalence of radiation-induced oral mucositis (OM) and associated factors. A cross-sectional retrospective study was performed at a reference dental care center. The medical records of patients submitted to radiotherapy for the treatment of head and neck cancer were used to collect clinical and demographic variables. The data were submitted to descriptive analysis and multivariate Poisson regression with robust variance [p<0.05; 95% confidence intervaI (CI)]. Four hundred and thirteen patients were analyzed. The mean age was 55±14 years. The prevalence of OM in the overall sample was 41.9% and was higher among males (78.2%). The following variables were significantly associated with the outcome: radiation dose [prevalence ratio (PR)= 1.04; 95% CI=1.02-1.06]; concomitant chemotherapy (PR=1.48, 95% CI=1.05-2.08); oral candidiasis (PR=1.97, 95% CI=1.44-2.68); and osteoradionecrosis (PR=1.51, 95% CI=1.10-2.06). Radiation-induced OM was associated with radiation dose, concomitant chemotherapy, oral candidiasis and osteoradionecrosis. The rate of OM underscores the importance of adequate oral care prior to treatment for head and neck cancer.

Citations

Mar 18, 2021·Scientific Reports·Beatriz Martines de SouzaAna Carolina Magalhães
Nov 26, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mara Luana Batista SeveroÉricka Janine Dantas da Silveira
Sep 19, 2020·Archives of Oral Biology·Vanessa Castro de Souza E SilvaEvandro Watanabe

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