Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor

Journal of Radiation Research
Satoru OchiaiNoriko Ii

Abstract

The aim of this retrospective study was to investigate characteristics of organizing pneumonia (OP) after stereotactic body radiotherapy (SBRT) for lung tumor. Between September 2010 and June 2014, patients who were diagnosed as Stage I lung cancer and treated with SBRT at our institution were included in this study. A total of 78 patients (47 males with a median age of 80 years) were analyzed. The median follow-up period was 23 months. Five patients (6.4%) developed OP at 6-18 months after SBRT. The cumulative incidence of OP was 4.3% (95% confidence interval [CI], 1.1-11.0) and 8.2% (95% CI, 2.9-17.0) at 1 and 2 years, respectively. Tumor location (superior and middle lobe vs inferior lobe) was shown to be a borderline significant factor for the occurrence of OP ( P: = 0.069). In the subgroup analysis of patients with a radiographic follow-up period at least 6 months, or who died within 6 months after SBRT, 7 of 72 patients (9.7%) developed Grade 2 or 3 radiation pneumonitis (G2/3 RP) at 2-4 months after SBRT. A statistically significant association between G2/3 RP in the subacute phase and OP was shown ( P: = 0.040). In two of the five patients who developed OP, the symptoms and radiographic change were improved rapidly by c...Continue Reading

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Citations

Jul 7, 2016·Journal of Radiation Research·Satoru OchiaiHajime Sakuma
Jan 31, 2017·International Journal of Molecular Sciences·Keisuke OtaniKazuhiko Ogawa
Nov 16, 2018·International Journal of Radiation Biology·Daniela StricklinJacob Bellman
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Jul 18, 2019·Respiratory Medicine Case Reports·Ruolin MaoZhihong Chen
Oct 30, 2020·International Journal of Radiation Oncology, Biology, Physics·Jeevin ShahiPatrick Cheung
Jun 15, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G ChassagnonM-P Revel
May 6, 2021·The Journal of International Medical Research·Shuang MaTianzi Jian

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EZR
R Foundation for Statistical Computing

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