PMID: 8958134Jan 1, 1997Paper

Radiation-induced oxidative DNA base damage and its repair in nuclear matrix-associated DNA and in bulk DNA in hepatic chromatin of rat upon whole-body gamma-irradiation

Free Radical Biology & Medicine
T H ZastawnyR Oliński

Abstract

In the present work, we examined the formation and repair of DNA base damages induced by gamma-irradiation in different fractions of rat hepatic chromatin. Animals were exposed to radiation with the dose of 10 Gy. Nuclear matrix DNA and whole chromatin were isolated from the liver of rats killed before and in different time after irradiation. In those samples the pyrimidine-derived and the purine-derived modified DNA bases were identified and quantitated by gas chromatography/isotope-dilution mass spectrometry with selected-ion monitoring. We found elevated levels of modified DNA bases over control values after whole body irradiation in both matrix DNA and bulk chromatin samples. Our results suggest that modified bases are preferentially removed from matrix DNA then bulk chromatin.

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Citations

Jun 28, 2002·Free Radical Biology & Medicine·Susan S Wallace
May 20, 1998·Free Radical Biology & Medicine·T H ZastawnyR Olinski
Feb 3, 2000·Free Radical Biology & Medicine·M A GraziewiczB Tudek
Mar 30, 2002·Critical Reviews in Oncology/hematology·Dimitrios Galaris, Angelos Evangelou
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Barbara Tudek
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Roger W L GodschalkHelmut Bartsch
Jun 11, 2015·The Journal of Physical Chemistry. B·Janusz RakŁukasz Golon
May 25, 2016·The Journal of Physical Chemistry. a·David M Close, Peter Wardman
Mar 29, 2001·Photochemistry and Photobiology·M J Gao, T M Murphy
Aug 8, 1997·The Journal of Biological Chemistry·K B Beckman, B N Ames

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