Radiation-Induced Painful Neurogenic Hypertrophy Treated With Botulinum Toxin A

Journal of Clinical Neuromuscular Disease
Alexandra FilippakisErik R Ensrud

Abstract

Painful neurogenic hypertrophy is a rare complication of radiation therapy. We report a 27-year-old woman with a history of adenoid cystic carcinoma of the submandibular gland presented with painful twitching of her left shoulder. Electrodiagnostic studies were consistent with a diagnosis of radiation-induced spinal accessory nerve hyperactivity. The patient failed conventional medical therapy. She was treated with an injection of botulinum toxin A, and within 1 month experienced significant relief of symptoms. We thus conclude that Botulinum toxin is a therapeutic option for the pain associated with radiation-induced peripheral nerve hyperactivity.

References

Jul 1, 1996·Muscle & Nerve·L Gutmann
Apr 27, 2010·Indian Journal of Dermatology·P K Nigam, Anjana Nigam
Mar 30, 2011·Neurology·Nicolas WeissJean-Yves Delattre

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Citations

Jan 18, 2020·Toxins·Shivam Om Mittal, Bahman Jabbari

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