PMID: 25749386Mar 10, 2015Paper

Radiation-induced PGE2 sustains human glioma cells growth and survival through EGF signaling

Oncotarget
Emeline BrocardLisa Oliver

Abstract

Glioblastoma Multiforme (GBM) is the most common brain cancer in adults. Radiotherapy (RT) is the most effective post-operative treatment for the patients even though GBM is one of the most radio-resistant tumors. Dead or dying cells within the tumor are thought to promote resistance to treatment through mechanisms that are very poorly understood. We have evaluated the role of Prostaglandin E2 (PGE2), a versatile bioactive lipid, in GBM radio-resistance. We used an in vitro approach using 3D primary cultures derived from representative GBM patients. We show that irradiated glioma cells produced and released PGE2 in important quantities independently of the induction of cell death. We demonstrate that the addition of PGE2 enhances cell survival and proliferation though its ability to trans-activate the Epithelial Growth Factor receptor (EGFR) and to activate β-catenin. Indeed, PGE2 can substitute for EGF to promote primary cultures survival and growth in vitro and the effect is likely to occur though the Prostaglandin E2 receptor EP2.

References

Nov 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J F Fowler
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·H K ShuM A Israel
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Jun 21, 2005·Nature Reviews. Cancer·John J Kim, Ian F Tannock
Nov 19, 2005·Science·Maria Domenica CastelloneJ Silvio Gutkind
Jan 9, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Petra Anna OhneseitHans Peter Rodemann
Jul 16, 2008·Methods : a Companion to Methods in Enzymology·Ola SöderbergUlf Landegren
Oct 8, 2009·Prostaglandins & Other Lipid Mediators·Katrin Andreasson
May 18, 2010·Current Opinion in Hematology·Ellen M Durand, Leonard I Zon
Oct 23, 2010·Cell Death and Differentiation·L LalierF M Vallette
Apr 29, 2011·BMC Cancer·Lisenn LalierChristophe Olivier
Nov 16, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yonghyun KimDo-Hyun Nam
Jun 26, 2013·Trends in Pharmacological Sciences·Jianxiong Jiang, Ray Dingledine
Nov 21, 2013·The Journal of Pathology·Debayan MukherjeeEric G Wright
Apr 12, 2014·Oncotarget·Chao KeYi-Hong Zhou
May 9, 2014·Oncotarget·Catherine GratasFrançois M Vallette
May 13, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joshua C AndersonChristopher D Willey

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Citations

Jun 30, 2018·International Journal of Molecular Medicine·Xiaoting Sun, Qi Li
Sep 21, 2018·Frontiers in Cellular Neuroscience·Xingchun GaoXingchun Gou
Jul 6, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna KockKarin Larsson
Jun 3, 2016·Expert Review of Anticancer Therapy·Nicole A P LiebermanCourtney A Crane
Apr 24, 2018·Journal of Immunotherapy·Noémie JoallandEmmanuel Scotet
May 9, 2018·Molecular Oncology·Jianlin GongStuart K Calderwood
Jun 21, 2020·Brain Sciences·Mayra Montecillo-AguadoSara Huerta-Yepez
May 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Steven W PoserAndreas Androutsellis-Theotokis
Mar 5, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ruirui ChenZhiqiang Li
Jul 29, 2021·International Journal of Cancer. Journal International Du Cancer·Nan LiShiwen Guo

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