Radiation-induced reductions in macrophage recruitment have only slight effects on myelin degeneration in sectioned peripheral nerves of mice

The European Journal of Neuroscience
V H PerryM C Brown

Abstract

Macrophage recruitment into the distal nerve stump of the cut or crushed sciatic or saphenous nerves of C57BL/6J mice was reduced by prior whole body irradiation. This procedure was successful in keeping the numbers of cells stained with the mouse macrophage-specific antibody F4/80 to the levels found in unsectioned nerves. Quantitative image analysis of immunostained sections showed that the rate of loss of myelin basic protein was identical in nerves from irradiated and unirradiated mice up to 5 days but thereafter was slower in macrophage-deprived nerves. Similar analysis of semithin sections stained with toluidine blue detected more undegenerated myelin in the nerves from irradiated mice 10 days after operation. Quantitative counts made from electron micrographs of the sectioned nerves at 7 days also showed slightly less extensive myelin breakdown in the nerves from irradiated mice. Complete removal of myelin from some Schwann cells can occur without macrophages, but macrophages accelerate the removal of myelin in the later stages of Wallerian degeneration. It is concluded that there are two phases to the breakdown of myelin in peripheral nerves undergoing Wallerian degeneration: an initial stage entirely dependent on the a...Continue Reading

References

Aug 1, 1986·Journal of Neurocytology·A J Crang, W F Blakemore
Oct 1, 1973·Journal of Neurochemistry·G R Webster
Oct 1, 1984·Journal of Neurocytology·W Beuche, R L Friede
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon

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Citations

Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Feb 4, 2012·Journal of Molecular Neuroscience : MN·Dong LouYouhua Wang
Oct 1, 1995·Current Opinion in Neurobiology·V H PerryM K Matyszak
Mar 23, 2004·Molecular and Cellular Neurosciences·Julia JungnickelClaudia Grothe
Mar 10, 2001·Progress in Neurobiology·R KieferH P Hartung
Dec 11, 2003·Molecular and Cellular Neurosciences·Susna DeSamuel David
Jul 2, 2008·Cell Research·Raffaella GozzelinoJoan X Comella
Nov 13, 2013·Nature Reviews. Neurology·Jami Scheib, Ahmet Höke
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mauricio E VargasBen A Barres
Mar 28, 1998·The European Journal of Neuroscience·C C da CostaW Brück
Apr 1, 1997·Brain Pathology·W Brück
May 18, 2007·Annual Review of Neuroscience·Mauricio E Vargas, Ben A Barres
Aug 30, 2013·Journal of Biomedical Science·Shao-Chun WuChing-Hua Hsieh
Sep 1, 2011·Journal of Neuroinflammation·Shlomo Rotshenker
Sep 1, 2011·Journal of Neuroinflammation·Andrew D GaudetMatt S Ramer
Apr 29, 2015·Mediators of Inflammation·Bruno Siqueira MiettoAna Maria Blanco Martinez
Oct 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jon P NiemiRichard E Zigmond
Jul 8, 2015·The Journal of Cell Biology·Jose A Gomez-SanchezKristján R Jessen
May 21, 2008·The Journal of Cell Biology·David B ParkinsonKristján R Jessen
Aug 22, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yukihiro KajitaTakahiro Ushida
Dec 30, 2014·Experimental Neurology·Edmund R HollisYimin Zou
Sep 29, 2004·Microscopy Research and Technique·Gürkan Oztürk, Ender Erdoğan
Feb 15, 2013·The European Journal of Neuroscience·Bruno Siqueira MiettoAna Maria Blanco Martinez
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Jan 18, 2014·Developmental Cell·Amanda Brosius Lutz, Ben A Barres
Jul 6, 2016·Frontiers in Cellular Neuroscience·André L BombeiroAlexandre L R Oliveira
Dec 6, 2001·The American Journal of Pathology·M MuellerR Kiefer
Feb 13, 2016·The Journal of Physiology·K R Jessen, R Mirsky
Sep 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Amanda Brosius LutzBen A Barres
Sep 29, 2005·The Journal of Bone and Joint Surgery. British Volume·S Hall
Nov 9, 2017·Oncotarget·Ching-Hua HsiehChia-Wei Lin

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