Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.

Molecular Therapy : the Journal of the American Society of Gene Therapy
Yuru MengRalph R Weichselbaum

Abstract

Radiotherapy offers an effective treatment for advanced cancer but local and distant failures remain a significant challenge. Here, we treated melanoma and pancreatic carcinoma in syngeneic mice with ionizing radiation (IR) combined with the poly(ADP-ribose) polymerase inhibitor (PARPi) veliparib to inhibit DNA repair and promote accelerated senescence. Based on prior work implicating cytotoxic T lymphocytes (CTLs) as key mediators of radiation effects, we discovered that senescent tumor cells induced by radiation and veliparib express immunostimulatory cytokines to activate CTLs that mediate an effective antitumor response. When these senescent tumor cells were injected into tumor-bearing mice, an antitumor CTL response was induced which potentiated the effects of radiation, resulting in elimination of established tumors. Applied to human cancers, radiation-inducible immunotherapy may enhance radiotherapy responses to prevent local recurrence and distant metastasis.

References

Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lanny Y XueAmin I Kassis
Jan 15, 2004·The Journal of Clinical Investigation·Pascal KahlemClemens A Schmitt
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Valérie SchreiberGilbert de Murcia
May 17, 2007·Current Medicinal Chemistry·R Aguilar-QuesadaF J Oliver
Jul 20, 2007·Methods in Molecular Biology·João F Passos, Thomas von Zglinicki
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna
Jul 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan Ashworth
Oct 1, 2008·European Journal of Immunology·Iñigo TirapuSandra S Diebold
Jan 20, 2009·Cold Spring Harbor Symposia on Quantitative Biology·V KrizhanovskyS W Lowe
Feb 3, 2009·Current Opinion in Genetics & Development·Gerard I Evan, Fabrizio d'Adda di Fagagna
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Arturo V OrjaloJudith Campisi
Jan 19, 2010·Annual Review of Pathology·Jean-Philippe CoppéJudith Campisi
Mar 4, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuru MengRalph R Weichselbaum
Apr 21, 2010·Seminars in Immunology·Yuting MaLaurence Zitvogel
Apr 23, 2010·Cancer Treatment Reviews·C PowellK J Harrington
Dec 17, 2010·Journal of Mammary Gland Biology and Neoplasia·Stephen L Shiao, Lisa M Coussens
Feb 16, 2011·The Journal of Cell Biology·Francis Rodier, Judith Campisi
May 17, 2011·Molecular Cancer Therapeutics·Juan Camilo Barreto-AndradeRalph R Weichselbaum
Jun 8, 2011·Genes & Development·Mickaël OhannaCorine Bertolotto
Jun 28, 2011·Nature Reviews. Cancer·Caterina NardellaPier Paolo Pandolfi

❮ Previous
Next ❯

Citations

Jul 31, 2013·Trends in Immunology·Laura SenovillaGuido Kroemer
May 3, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Michael P Brown
Jan 8, 2013·Journal of the National Cancer Institute·Silvia C Formenti, Sandra Demaria
Jan 18, 2014·International Journal of Molecular Sciences·Bonggoo ParkKyung-Mi Lee
Feb 22, 2013·Science Translational Medicine·Stanley L LiauwRalph R Weichselbaum
Jun 15, 2014·Journal of Cancer Research and Clinical Oncology·Yuli LiYuquan Wei
Nov 17, 2015·International Journal of Molecular Sciences·Byeong Mo KimYonggeun Hong
Mar 22, 2016·Analytical Cellular Pathology (Amsterdam)·Arif MalikMahmood Rasool
Mar 5, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yuting MaLaurence Zitvogel
Jul 16, 2014·Biochimica Et Biophysica Acta·Barbara Lupo, Livio Trusolino
Jan 17, 2019·Physiological Reviews·Arianna CalcinottoAndrea Alimonti
Jan 1, 2019·Acta Physiologica·Ferruh ArtuncBernhard N Bohnert
Sep 4, 2019·Nature Communications·Ainhoa ArinaRalph R Weichselbaum
Apr 29, 2020·Cancers·Jehad F AlhmoudMohammed Imad Malki
Apr 30, 2016·Oncotarget·Edwardine LabayRalph R Weichselbaum
Nov 17, 2016·Oncotarget·Kelli A ConnollyScott A Gerber
Dec 27, 2016·Science Immunology·Michael SpiottoRalph R Weichselbaum
Aug 28, 2020·Radiation Research·Nipa H PatelDavid A Gewirtz
Sep 12, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ren LuoGabriele Niedermann
Oct 17, 2017·Molecular Cancer Therapeutics·Elena V EfimovaStephen J Kron
Nov 17, 2020·Oncoimmunology·Ben G L VannesteDirk De Ruysscher
Feb 10, 2020·International Journal of Radiation Oncology, Biology, Physics·Steven N SeyedinJoseph M Caster
Jun 3, 2021·International Journal of Molecular Sciences·Chandrasekharam N NagineniJames B Mitchell
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Jing YangXing Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.