Radiation Oncology in the 21st Century: Prospective Randomized Trials That Changed Practice… or Didn't!

Frontiers in Oncology
Kaveh ZakeriBhadrasain Vikram

Abstract

In a two-part article published in 2009, we discussed the limitations of conventional radiation therapy, the challenges of studying new technologies in radiation oncology, and summarized the state-of-the science for various malignancies (1, 2). Here, we summarize some of the most important prospective, randomized trials that during the intervening years have attempted to improve the tumor control and/or decrease the adverse effects of radiation therapy. For consistency, we have focused here on the null and alternate hypotheses as articulated by the investigators at the onset of each trial, since the outcome of the investigational treatment should be considered clinically significant only if the null hypothesis was rejected. The readers (and patients) are of course free to make their own judgments about the clinical significance of the results when the null hypothesis was not rejected.

References

Feb 22, 1990·The New England Journal of Medicine·R A PatchellB Young
Feb 12, 2010·The New England Journal of Medicine·Timothy J WhelanCarolyn Freeman
Jul 15, 2011·The New England Journal of Medicine·Christopher U JonesWilliam U Shipley
Apr 20, 2012·The New England Journal of Medicine·Nicholas D JamesUNKNOWN BC2001 Investigators
Jun 1, 2012·The New England Journal of Medicine·P van HagenUNKNOWN CROSS Group
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin J van den BentKhê Hoang-Xuan
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory CairncrossMinesh Mehta
Jul 19, 2013·The New England Journal of Medicine·C ParkerUNKNOWN ALSYMPCA Investigators
May 20, 2014·Lancet·Joanne S HavilandJudith M Bliss
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K Kian AngRita S Axelrod
Jul 23, 2015·The New England Journal of Medicine·Timothy J WhelanUNKNOWN MA.20 Study Investigators
Jul 23, 2015·The New England Journal of Medicine·Philip M PoortmansUNKNOWN EORTC Radiation Oncology and Breast Cancer Groups
Dec 17, 2015·JAMA : the Journal of the American Medical Association·Roger StuppZvi Ram
Feb 18, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K BujkoUNKNOWN Polish Colorectal Study Group
Apr 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Robert LeeHoward M Sandler
Apr 7, 2016·The New England Journal of Medicine·Jan C BucknerWalter J Curran
Oct 27, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan NymanIngmar Lax
Sep 15, 2016·The New England Journal of Medicine·Freddie C HamdyUNKNOWN ProtecT Study Group
Sep 15, 2016·The New England Journal of Medicine·J L DonovanUNKNOWN ProtecT Study Group*
Feb 2, 2017·The New England Journal of Medicine·William U ShipleyUNKNOWN NRG Oncology RTOG
Mar 16, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles N CattonMark N Levine
Jun 6, 2017·The New England Journal of Medicine·Nicholas D JamesUNKNOWN STAMPEDE Investigators
Jun 27, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Elizabeth M GoreJeffrey D Bradley
Sep 9, 2017·The New England Journal of Medicine·Scott J AntoniaUNKNOWN PACIFIC Investigators
Jan 3, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhongxing LiaoRadhe Mohan

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