PMID: 11917281Mar 28, 2002Paper

Radiation pneumonitis and early circulatory cytokine markers

Seminars in Radiation Oncology
Yuhchyau ChenPaul Okunieff

Abstract

Radiation pneumonitis is a distinct clinical entity that differs from other pulmonary symptoms such as allergic pneumonitis, chemical pneumonitis, or pneumonia by various infectious agents. Recent research has supported the mechanism of cellular interaction between lung parenchymal cells and circulating immune cells mediated through a variety of cytokines including proinflammatory cytokines, chemokines, adhesion molecules, and profibrotic cytokines. Identifying reliable biomarkers for radiation pneumonitis will allow us to identify individuals at risk for pneumonitis before or during the early stage of therapy. Prospective blood sampling, scoring of respiratory symptoms, and chest imaging were conducted for patients receiving thoracic radiotherapy for malignancy. Serial plasma specimens were analyzed for circulating cytokine changes before, during, and up to 12 weeks after radiation. Radiation pneumonitis was diagnosed using National Cancer Institute (NCI) common toxicity criteria. Cytokine analysis was assayed for interleukin 1alpha (IL-1alpha), interleukin 6 (IL-6), monocyte chemotactic protein 1 (MCP-1), E-selectin, L-selectin, transforming growth factor beta1 (TGF-beta1), and basic fibroblast growth factor (bFGF) using enzy...Continue Reading

References

Jan 1, 1977·Annals of Internal Medicine·N J Gross
Nov 1, 1978·International Journal of Radiation Oncology, Biology, Physics·C J FryerP Poon
Nov 1, 1990·American Journal of Respiratory Cell and Molecular Biology·R M KotloffJ A Elias
Jun 1, 1988·European Journal of Immunology·M HelleL A Aarden
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M RoachT L Phillips
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·P RubinJ N Finkelstein
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·S McDonaldL B Marks
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·P MaasiltaK Mattson
May 1, 1993·Annals of Internal Medicine·C M RobertsS N Breit
Apr 5, 1996·Science·E C Butcher, L J Picker
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B ReckzehK Havemann
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·M S AnscherR L Jirtle
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·S L KwaR K Ten Haken
Mar 23, 2000·The Journal of Pathology·W I de BoerP S Hiemstra
Jul 6, 2000·The Journal of Laboratory and Clinical Medicine·M SchuylerA Cherne
Jul 11, 2000·Clinical and Experimental Immunology·M KasedaS Kohno
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·Y ChenP Okunieff

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Citations

Oct 7, 2003·American Journal of Clinical Oncology·Paul OkunieffUNKNOWN Radiation Oncology Committee of the Southwest Oncology Group
Sep 26, 2003·Seminars in Surgical Oncology·Yuhchyau ChenSteven A Ahrendt
Apr 2, 2004·Nature Reviews. Cancer·Stephen T Sonis
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitchell S Anscher
Nov 1, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chiharu TabataMichiaki Mishima
Oct 7, 2006·American Journal of Respiratory and Critical Care Medicine·Chiharu TabataHajime Kubo
Apr 9, 2010·Radiation Oncology·Toshiyuki OgataNariaki Matsuura
Sep 18, 2012·Experimental and Therapeutic Medicine·Toshiyuki OgataNariaki Matsuura
Jan 18, 2012·International Journal of Radiation Biology·Willie J BrickeyJenny P-Y Ting
Apr 8, 2014·Radiation Research·Alexandra PaunChristina K Haston
Oct 5, 2016·Biomedical Reports·Justyna Chalubinska-FendlerJacek Fijuth
Mar 20, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jinbo YueXin Shelley Wang
Oct 9, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M MorenoR Martínez-Monge
Jan 23, 2014·Experimental Lung Research·Bao-Zhong WangLe-Xin Wang
Apr 19, 2015·Radiation Oncology·Alexandra PaunChristina K Haston
Jun 2, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rahul GuptaG R Verma
Aug 2, 2017·The Journal of Clinical Investigation·Gregory S WhiteheadDonald N Cook
Mar 3, 2018·International Journal of Molecular Sciences·Chao RongJochen Hess
Apr 18, 2019·Radiation Research·Jane BryantFiona Lynga
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul OkunieffLynn H Gerber
Apr 23, 2008·Cancer Metastasis Reviews·Eva ChristensenRobert G Bristow
Dec 8, 2006·Radiation Research·Roxana G BalunaCharles R Thomas
Apr 1, 2008·Cancer Control : Journal of the Moffitt Cancer Center·Feng-Ming KongTheodore S Lawrence
Jan 23, 2008·The British Journal of Radiology·M NomuraK Takeda
Sep 24, 2010·BMC Cancer·Miao-Fen ChenYin-Hsuan Cheng
May 29, 2008·Cancer Metastasis Reviews·Paul OkunieffAmy K Huser
May 18, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Dongqing WangHongfu Sun
Jun 30, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Biji MathewJoe G N Garcia

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