Dec 1, 1995

Radiation protection and radiation recovery with essential metalloelement chelates

Proceedings of the Society for Experimental Biology and Medicine
J R SorensonL W Chang

Abstract

Understanding essential metalloelement metabolism and its role in tissue maintenance and function, as well as the roles of essential metalloelement-dependent enzymes in responding to injury, offer a new approach to decreasing and/or treating radiation injury. This review presents the roles of some essential metalloelement-dependent enzymes in tissue maintenance and function, and their responses to radiation injury in accounting for radiation protection and recovery effects observed for nontoxic doses of essential metalloelement compounds. Effects of biochemicals including water undergoing bond radiolysis and the effects of free radicals derived from diatomic oxygen account for the acute and chronic aspects of radiation injury. Recognized biochemical roles of essential metalloelement-dependent enzymes and the observed pharmacological effects of small-molecular mass chelates predict the therapeutic usefulness of essential metalloelement complexes in decreasing and/or treatment of radiation injury. Copper chelates have radiation protection and radiation recovery activities and cause rapid recovery of immunocompetency and recovery from radiation-induced histopathology. Mice treated with Cu(II)2(3,5-diisopropylsalicylate)4[Cu (II)2(...Continue Reading

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Mentioned in this Paper

Metabolic Process, Cellular
Enzymes, antithrombotic
Spleen
Neoplasm of Uncertain or Unknown Behavior of Thymus
Complex (molecular entity)
Small Intestinal Wall Tissue
Bone Marrow
Free Radicals
Disease of Thymus Gland
Metals

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