PMID: 9537656Apr 16, 1998Paper

Radiation-related adverse effects observed on neuro-imaging several years after radiosurgery for cerebral arteriovenous malformations

Surgical Neurology
M YamamotoI Saito

Abstract

To our knowledge, there are no reported arteriovenous malformation (AVM) series in which detailed long-term follow-up results after radiosurgery were described based on the whole patient group. We performed a detailed long-term follow-up study of 53 patients with cerebral AVMs treated with gamma knife (GK) radiosurgery, with emphasis on radiation-related adverse effects detected on neuro-imaging after a long post-irradiation latency period (3-10 years). The post-GK follow-up period was 40-232 months excluding two mortalities, the mean being 112 and the median being 111 months. Three patients (5.6%) have, as yet, refused all neuro-imaging follow-up studies. Complete nidus obliteration was confirmed angiographically in 32 patients (60.4%) between 1 and 5 post-GK years. In the other 18 patients (34%), despite significant nidus shrinkage being angiographically demonstrated, complete obliteration was not achieved during a 2-7 year follow-up period. There were two mortalities, one AVM-related (massive re-bleeding during the latency period) and the other angiography-related. There were five radiation-related morbidities (9.4%), three of which-hemi-Parkinson syndrome, hemiparesis, and visual field disturbances attributable to delayed c...Continue Reading

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Citations

Jan 18, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Antonio NicolatoAlbino Bricolo
May 18, 2011·Neurosurgical Review·Ioannis LoumiotisMichael Link
Jun 8, 2001·Current Treatment Options in Neurology·Deborah M. Costakos, Jeffrey L. Bennett
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