Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer.

Oncogene
Marsha-Kay N D HutchinsonNisha J D'Silva

Abstract

Radiation is a significant treatment for patients with head and neck cancer. Despite advances to improve treatment, many tumors acquire radiation resistance resulting in poor survival. Radiation kills cancer cells by inducing DNA double-strand breaks. Therefore, radiation resistance is enhanced by efficient repair of damaged DNA. Head and neck cancers overexpress EGFR and have a high frequency of p53 mutations, both of which enhance DNA repair. This review discusses the clinical criteria for radiation resistance in patients with head and neck cancer and summarizes how cancer cells evade radiation-mediated apoptosis by p53- and epidermal growth factor receptor (EGFR)-mediated DNA repair. In addition, we explore the role of cancer stem cells in promoting radiation resistance, and how the abscopal effect provides rationale for combination strategies with immunotherapy.

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Citations

Jul 15, 2020·Cells·María Auxiliadora Olivares-UrbanoMaría Isabel Núñez
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Gan Huang, Shu-Ting Pan
Feb 7, 2021·International Journal of Molecular Sciences·Rüveyda DokSandra Nuyts
Apr 23, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Xinrui ZhangLisa Landgraf
Jul 3, 2021·Biomolecules·Jacek KabzinskiIreneusz Majsterek
Jun 25, 2021·International Journal of Radiation Oncology, Biology, Physics·Konstanze LettauMahmoud Toulany
Jun 11, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rajat BanerjeeNisha J D'Silva

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Methods Mentioned

BETA
X-ray
PCR

Clinical Trials Mentioned

NCT01893307
NCT03799445
NCT03509012
NCT03426657
NCT02999087
NCT02764593
NCT03623646
NCT03546582
NCT03522584
NCT03317327

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