Radiation Retinopathy 47 Years following Brachytherapy for Retinoblastoma

Ocular Oncology and Pathology
Claudine Bellerive, Arun D Singh

Abstract

A 50-year-old female who had undergone enucleation in the left eye and brachytherapy in the right eye for retinoblastoma at the age of 2 years was diagnosed with nonproliferation radiation retinopathy 47 years following the initial treatment. The patient had noticed black spots in her vision (scotomas) that interfered with reading. New onset of microaneurysms and lipid exudation threatening the foveola was noted on examination of the right eye. Initial visual acuity (VA) was 20/25. Optical coherence tomography showed no evidence of macular edema, but parafoveal lipid exudation was present. On fluorescein angiography, no sign of neovascularization or macular ischemia was observed. Direct focal treatment of microaneurysms was performed to prevent progression of the radiation retinopathy and vision loss. At 18 months' follow-up following focal laser, VA remained stable at 20/25 and there was a regression of the retinopathy.

References

Jun 1, 1987·Ophthalmic Paediatrics and Genetics·C StannardJ Korrubel
Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D G PradhanA J Gray
Aug 26, 1998·Ophthalmology·P G HykinJ F Arevalo
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·C StannardR Knowles
Jul 6, 2004·Pediatric Blood & Cancer·Thomas E MerchantBarrett G Haik
Sep 8, 2004·Ophthalmology·Ilkka PuusaariTero Kivelä
Oct 1, 2007·Retinal Cases & Brief Reports·Stephen J Kim, G Baker Hubbard
Dec 2, 2014·International Ophthalmology Clinics·Hassan A Aziz, Arun D Singh

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