Radiation sources providing increased UVA/UVB ratios induce photoprotection dependent on the UVA dose in hairless mice

Photochemistry and Photobiology
Vivienne E ReeveMichael Slater

Abstract

In studies involving mice in which doses of UVA (320-400 nm) and UVB (290-320 nm) radiation were administered alone or combined sequentially, we observed a protective effect of UVA against UVB-induced erythema/edema and systemic suppression of contact hypersensitivity. The UVA immunoprotection was mediated by the induction of the stress enzyme heme oxygenase-1 (HO-1) in the skin, protection of the cutaneous Th1 cytokines interferon-gamma (IFN-gamma) and IL-12 and inhibition of the UVB-induced expression of the Th2 cytokine IL-10. In this study, we seek evidence for an immunological waveband interaction when UVA and UVB are administered concurrently to hairless mice as occurs during sunlight exposure in humans. A series of spectra providing varying ratios of UVA/UVB were developed, with the UVA ratio increased to approximately 3.5 times the UVA component in solar simulated UV (SSUV). We report that progressively increasing the UVA component of the radiation while maintaining a constant UVB dose resulted in a reduction of both the erythema/edema reaction and the degree of systemic immunosuppression, as measured as contact hypersensitivity. The UVA-enhanced immunoprotection was abrogated in mice treated with a specific HO enzyme i...Continue Reading

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Citations

Apr 19, 2007·Cancer Immunology, Immunotherapy : CII·Munif Allanson, Vivienne E Reeve
Mar 10, 2010·Immunology and Cell Biology·Mahesh BandaraVivienne Elizabeth Reeve
May 20, 2008·Photomedicine and Laser Surgery·Wonbong LimHongran Choi
Mar 4, 2008·International Journal of Biological Sciences·James D HoerterLeah Vanderhill
Jul 8, 2008·Cell Calcium·Yan Dong ZhouZong Jie Cui
Apr 25, 2007·Journal of Photochemistry and Photobiology. B, Biology·Jeffrey R Kanofsky, Paul D Sima
Dec 27, 2008·The Journal of Investigative Dermatology·Vivienne E ReeveLynette Blyth
Sep 11, 2014·Photochemistry and Photobiology·Muhammad Farrukh NisarJulia Li Zhong
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Wannit Tongkao-OnRebecca S Mason
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Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Vivienne E ReeveNicole Painter
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