PMID: 3770028May 1, 1986Paper

Radiation studies on multicellular tumour spheroids derived from human neuroblastoma: absence of sparing effect of dose fractionation

European Journal of Cancer & Clinical Oncology
T E WheldonA Gregor

Abstract

In vitro experiments were carried out to compare the effects of single-dose and split-dose irradiation on a cell line (NB1-G) derived from human neuroblastoma and grown as multicellular tumour spheroids (MTS). The radiation response was evaluated in terms of regrowth delay; estimates of in situ cell survival were made by back-extrapolation of regrowth curves. These studies showed no significant difference in the effectiveness of single as compared to split dose irradiation i.e. no sparing effect of fractionation. If MTS constitute a realistic model for micrometastases in vivo, these results provide a radiobiological rationale for hyperfractionated treatment regimes in the adjuvant radiotherapy of neuroblastoma.

References

Jan 1, 1985·International Journal of Radiation Oncology, Biology, Physics·M V WilliamsJ F Fowler
Jun 1, 1985·International Journal of Radiation Oncology, Biology, Physics·H P Beck-BornholdtT C Stephens
Apr 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J M DeaconM J Peckham
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J DeaconG G Steel
Jan 1, 1984·Cancer Chemotherapy and Pharmacology·T Nederman, J Carlsson
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·G W Barendsen
Feb 1, 1983·International Journal of Radiation Oncology, Biology, Physics·H D ThamesL Milas
Apr 1, 1980·International Journal of Radiation Oncology, Biology, Physics·R R WeichselbaumJ B Little
Feb 1, 1980·International Journal of Radiation Oncology, Biology, Physics·M D WharamS E Order
Feb 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H D ThamesG H Fletcher
May 1, 1981·International Journal of Radiation Oncology, Biology, Physics·B Fertil, E P Malaise

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Citations

Nov 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J H SchwachöferA G Theeuwes
Jun 7, 2005·Cancer Letters·Anthony G McCluskeyRobert J Mairs
Oct 18, 2000·Critical Reviews in Oncology/hematology·C DubessyF Guillemin
Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J H SchwachöferA G Theeuwes
Sep 1, 1987·International Journal of Radiation Oncology, Biology, Physics·T E WheldonA Gregor
Aug 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seong-Kyoon ChoiWon Bae Jeon
Jun 1, 1991·Journal of Medical Ethics·W G Pickering

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