Radiation synovectomy with yttrium-90 for persisting arthritis has direct harmful effects on human cartilage that cannot be prevented by co-administration of glucocorticoids: an in vitro study.

Annals of the Rheumatic Diseases
Z N JahangierF P J G Lafeber

Abstract

It was recently shown that radiation synovectomy with yttrium-90 (90Y) and glucocorticoids is not superior to intra-articular glucocorticoids alone in the treatment of persistent gonarthritis. In that study, it seemed that in patients treated by radiation synovectomy, progression of radiographic joint damage occurred. To test in vitro the direct effects of radiation synovectomy with 90Y on human cartilage. Human cartilage tissue was exposed to 90Y, glucocorticoids or the combination. 1:2000 to 1:20 dilutions of the clinical dose of 5 mCi/ml 90Y and 20 mg/ml glucocorticoids were used. After a 4-day exposure and a subsequent 12-day recovery period, proteoglycan synthesis, proteoglycan release and proteoglycan content were measured. In addition, human synovial tissue was cultured for 4 days with 90Y or glucocorticoids. Culture supernatants were analysed for cartilage-destructive activity. 90Y, glucocorticoids and the combination inhibited proteoglycan synthesis considerably and dose dependently, an effect that sustained for at least 12 days. Proteoglycan release was transiently increased by 90Y, an effect that was not changed by addition of glucocorticoids, which had no effect on its own. Proteoglycan content was eventually advers...Continue Reading

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Citations

Jun 4, 2011·Rheumatology International·Robert ZwolakBeata Chrapko
Sep 27, 2012·Cancer Biotherapy & Radiopharmaceuticals·Rubel ChakravartyM R A Pillai
Jul 30, 2009·International Journal of Radiation Biology·Peter L E M van LentWim B van den Berg
Oct 5, 2010·Seminars in Arthritis and Rheumatism·Sébastien OttavianiLaure Gossec
May 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Doris GabrielNorbert Lange
Oct 28, 2008·British Journal of Haematology·Nathalie W D JansenFloris P J G Lafeber
Jun 28, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Vincent AndréGrégoire Cormier
May 29, 2012·Australian Veterinary Journal·S A VallanceC B O'Sullivan
Apr 13, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Kai KisielinskiJosef G Fitzek

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