Radiation therapy for nasal vestibule squamous cell carcinoma: a 40-year experience

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Justin WrayW M Mendenhall

Abstract

We evaluated the treatment of squamous cell carcinoma (SCC) of the nasal vestibule. Eighty-six patients were treated with radiotherapy (RT) and 13 patients received surgery and RT. The mean follow-up was: 9.7 years (range 4 months-35.9 years). The 5- and 10-year outcomes were: local control (LC), 88 and 82 %; local-regional control (LRC), 78 and 73 %; freedom from distant metastases (FFDM), 96 and 96 %; cause-specific survival (CSS), 91 and 86 %; and overall survival, 75 and 51 %. The 5- and 10-year LC rates for patients treated with RT were 94 and 89 % overall. A multivariate analysis was performed. Tumor size predicted LC, LRC, OS, and CSS. Overall stage predicted LRC. RT cures most patients with T1-T2 and favorable T4 SCCs with acceptable toxicity. RT and surgery result in improved likelihood of cure for patients with advanced T4 lesions.

References

May 7, 2004·The New England Journal of Medicine·Jay S CooperUNKNOWN Radiation Therapy Oncology Group 9501/Intergroup
May 7, 2004·The New England Journal of Medicine·Jacques BernierUNKNOWN European Organization for Research and Treatment of Cancer Trial 22931
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·Johannes A LangendijkBerend J Slotman
Jul 15, 2006·International Journal of Radiation Oncology, Biology, Physics·Peter C LevendagStefan O P Hofer
Apr 22, 2008·The Journal of Laryngology and Otology·A DowleyN S Jones
Jan 21, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carol M LewisRandal S Weber

❮ Previous
Next ❯

Citations

Dec 7, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yuki MukaiGabriela Studer
Aug 3, 2019·Clinical and Experimental Otorhinolaryngology·Michaela PlathPhilippe A Federspil
Jul 3, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Domenic VitalKristian Ikenberg
Dec 29, 2020·Indian Journal of Surgical Oncology·S Vijendra ShenoyM Panduranga Kamath
Mar 6, 2021·Current Opinion in Otolaryngology & Head and Neck Surgery·Subramania IyerN Nageswara Rao
Oct 29, 2021·Acta Oncologica·Mads V FiltenborgKristian B Petersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.