Radiation therapy for recurrent heterotopic ossification prophylaxis after partial metatarsal amputation

The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons
Troy J BoffeliJonathan C Thompson

Abstract

The formation of heterotopic ossification is a relatively common, yet rarely discussed, cause of re-ulceration after previous partial metatarsal amputation. Excessive bone growth at the amputation site has the potential to create an unwanted prominence on the weightbearing surface of the foot, intuitively increasing plantar pressure and placing the neuropathic patient at greater risk of re-ulceration and limb loss. The aim of the present study was to assess the efficacy of single-dose radiation therapy in preventing recurrent heterotopic ossification. The inclusion criteria consisted of a history of clinically relevant heterotopic ossification formation after partial metatarsal amputation with subsequent partial metatarsal amputation for heterotopic ossification resection, followed by prophylactic single-dose radiation therapy. Eleven consecutive patients meeting the inclusion criteria were identified for the present study. Before the intervention, 10 (91%) patients demonstrated formation of mid- to high-grade heterotopic ossification, and 9 (82%) patients exhibited an associated neuropathic ulceration. On follow-up at least 6 weeks after intervention, 2 (18%) patients exhibited low-grade heterotopic ossification reformation th...Continue Reading

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Dec 19, 2012·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Troy J Boffeli, Matthew C Peterson

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Citations

Feb 29, 2016·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Troy J BoffeliKevin J Mahoney
Aug 26, 2018·Clinical and Experimental Pharmacology & Physiology·Paweł ŁęgoszPaweł Małdyk

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