PMID: 3759524Oct 1, 1986Paper

Radiation therapy for unresectable soft tissue sarcomas

International Journal of Radiation Oncology, Biology, Physics
J D SlaterL J Peters

Abstract

Between 1954 and 1981, 72 patients with unresectable soft tissue sarcomas were treated with radiotherapy at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 57 with photons alone and 15 with neutrons for at least part of the treatment. Twenty-three patients received systemic chemotherapy in addition to radiation therapy. The absolute 2-year and actuarial 5-year tumor control rates were 39 and 29%, respectively. In this heterogeneous series, the malignancy group (based on pathologic diagnosis) was the only factor significantly affecting tumor control probability, which at 5 years was 58% for 12 patients with group I tumors, 32% for 10 patients with group II tumors, and 17% for 50 patients with group III tumors. No relationship between total dose and tumor control probability was found in this group of patients, though the duration of tumor control was longer in those receiving 65 Gy or more. No apparent improvement in tumor control was observed in the subsets of patients receiving fast neutron therapy or combined modality treatment with chemotherapy, but because of the many unmatched variables between the groups, no meaningful comparison of treatment modalities can be made. Distant metastasis were ...Continue Reading

References

Jun 1, 1978·Cancer·S W Weiss, F M Enzinger
Dec 1, 1979·The American Journal of Surgical Pathology·H L Evans
Jan 1, 1975·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·R D LindbergM M Romsdahl
May 1, 1985·Cancer·L J PetersT Johnson
Jan 1, 1985·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R V O'TooleH M Sharma
Aug 1, 1983·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G SchmittE Scherer
Mar 1, 1984·The British Journal of Radiology·G SchmittC Streffer
Aug 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J J Battermann, K Breur
Dec 1, 1982·International Journal of Radiation Oncology, Biology, Physics·A Wambersie
Aug 15, 1981·Cancer·A G WileM M Romsdahl

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Citations

Aug 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ángel Montero LuisJosé Antonio López Martín
Oct 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S CakirS Okkan
Dec 1, 1989·Cancer Treatment Reviews·A Krarup-Hansen, H S Poulsen
Nov 1, 1995·Critical Reviews in Oncology/hematology·R P VethM Pruszczynski
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Lucyna KepkaSaveli I Goldberg
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·W RhombergD Gefeller
Jun 4, 2008·Sarcoma·Vivien H C Bramwell
May 1, 1997·Australasian Radiology·A Visioli, F J Daniel
Jan 6, 2009·Wiener klinische Wochenschrift·Hildegard PapeEdwin Bölke
Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·J L HabrandM Albano
Nov 5, 2014·Journal of Surgical Oncology·Eric D MillerKarl E Haglund
Oct 1, 1986·American Journal of Surgery·R S WeberH Goepfert
Jun 3, 2008·The Surgical Clinics of North America·Aradhana Kaushal, Deborah Citrin
Jan 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil SenzerNader Hanna
Oct 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M RobinsonG Westbury
Dec 30, 2017·Human Gene Therapy·Shao Wen XiaoShan Wen Zhang
Jul 22, 2018·Cancer Medicine·Reiko ImaiUNKNOWN Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas
Feb 15, 1992·Cancer·C W StevensJ Torrisi
Jan 1, 1987·Langenbecks Archiv für Chirurgie·H P Bruch
Nov 29, 2016·Clinical Sarcoma Research·Adam DangoorIan Judson
Feb 1, 1997·Acta Orthopaedica Scandinavica. Supplementum·S Y Ngan

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