PMID: 7023642May 15, 1981Paper

Radiation Therapy Oncology Group clinical trials with misonidazole

Cancer
T H WassermanT L Phillips

Abstract

This paper presents a review of the progressive clinical trials of the hypoxic cell radiosensitizer, misonidazole, in the Radiation Therapy Oncology Group (RTOG). Presentation is made of all the schemas of the recently completed and currently active RTOG Phase II and Phase III studies. Detailed information is provided on the clinical toxicity of the Phase II trials, specifically regarding neurotoxicity. With limitations in drug total dose, a variety of dose schedules have proven to be tolerable, with a moderate incidence of nausea and vomiting and mild peripheral neuropathy, and a low incidence of more severe peripheral neuropathy or central neuropathy. No other organ toxicity has been seen, specifically no liver, renal or bone marrow toxicities. The clinical pharmacologic monitoring of misonidazole blood levels has been satisfactory with good correlation between the group-wide (Phase II) UV values and the HPLC values from the Phase I study. The patient accrual of the trials has been rapidly increasing and an early analysis suggests efficacy better than previous radiation experience. A series of eight Phase III trials are currently underway or proposed in the RTOG and the results of these are pending. An additional Phase III ma...Continue Reading

References

Jun 1, 1979·International Journal of Radiation Oncology, Biology, Physics·T H WassermanG VanRaalte
Dec 27, 1979·The New England Journal of Medicine·J D Chapman
Feb 1, 1980·The British Journal of Radiology·T H WassermanJ M Strong
Jan 1, 1981·International Journal of Radiation Oncology, Biology, Physics·S C CarabellR L Goodman

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Citations

Nov 1, 1988·Journal of Neuro-oncology·B MelgaardO B Paulson
Jun 1, 1985·International Journal of Radiation Oncology, Biology, Physics·J L Born, W M Hadley
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·C N ColemanT L Phillips
Apr 5, 2001·International Journal of Radiation Oncology, Biology, Physics·S XuJ A Koutcher
Nov 26, 1999·International Journal of Radiation Oncology, Biology, Physics·R A MillerJ A Koutcher
May 30, 1991·The New England Journal of Medicine·P M Black
Aug 1, 1997·American Journal of Clinical Oncology·H K KimH M Sandler
Mar 1, 1991·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M J BorrelliG Iliakis
Oct 1, 1983·International Journal of Radiation Oncology, Biology, Physics·P J EifelJ M Brown
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·T L PhillipsL W Brady
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·B J CummingsR S Bush
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·C N ColemanG Zagars
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·C N ColemanJ M Brown
Dec 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Hederman
Jun 1, 1981·International Journal of Radiation Oncology, Biology, Physics·T H Wasserman
Aug 1, 1987·International Journal of Radiation Oncology, Biology, Physics·J FazekasJ Stetz
Sep 1, 1983·International Journal of Radiation Oncology, Biology, Physics·M A FathiM M Elhilali
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·T H WassermanD VonGerichten
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·C N ColemanV K Hirst
Jun 15, 1994·International Journal of Radiation Oncology, Biology, Physics·T TadaS Inayama
Dec 1, 1984·International Journal of Radiation Oncology, Biology, Physics·S S HongT Matsuzawa
Sep 1, 1982·Annals of Neurology·W R Shapiro
Oct 22, 2004·Seminars in Oncology·Stuart A Grossman, Julette F Batara
Nov 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C MurayamaT Mori

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