Radiation Therapy to the Plexus Brachialis in Breast Cancer Patients: Analysis of Paresthesia in Relation to Dose and Volume

International Journal of Radiation Oncology, Biology, Physics
Dan LundstedtPer Karlsson

Abstract

To identify volume and dose predictors of paresthesia after irradiation of the brachial plexus among women treated for breast cancer. The women had breast surgery with axillary dissection, followed by radiation therapy with (n=192) or without irradiation (n=509) of the supraclavicular lymph nodes (SCLNs). The breast area was treated to 50 Gy in 2.0-Gy fractions, and 192 of the women also had 46 to 50 Gy to the SCLNs. We delineated the brachial plexus on 3-dimensional dose-planning computerized tomography. Three to eight years after radiation therapy the women answered a questionnaire. Irradiated volumes and doses were calculated and related to the occurrence of paresthesia in the hand. After treatment with axillary dissection with radiation therapy to the SCLNs 20% of the women reported paresthesia, compared with 13% after axillary dissection without radiation therapy, resulting in a relative risk (RR) of 1.47 (95% confidence interval [CI] 1.02-2.11). Paresthesia was reported by 25% after radiation therapy to the SCLNs with a V40 Gy ≥ 13.5 cm(3), compared with 13% without radiation therapy, RR 1.83 (95% CI 1.13-2.95). Women having a maximum dose to the brachial plexus of ≥55.0 Gy had a 25% occurrence of paresthesia, with RR 1.8...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Jul 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S PowellC Parsons
Apr 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·N K OlsenC Rose
Jul 20, 1999·JAMA : the Journal of the American Medical Association·I AtroshiI Rosén
Jul 21, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·K H Wittenberg, M C Adkins
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Silvia JohanssonJuliana Denekamp
Jul 18, 2002·Journal of the National Cancer Institute·UNKNOWN International Breast Cancer Study Group (IBCSG)
Jun 3, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Amira BajrovicWinfried Alberti
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Søren M BentzenEllen D Yorke
Jul 21, 2010·International Journal of Radiation Oncology, Biology, Physics·Ann-Charlotte WaldenströmGunnar Steineck
Sep 10, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Elaine S WaiIvo A Olivotto
Oct 19, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Indra J DasLawrence J Solin
Oct 26, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dan LundstedtPer Karlsson
Jan 31, 2012·International Journal of Radiation Oncology, Biology, Physics·Arya AminiJames Welsh
Feb 11, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dan LundstedtPer Karlsson
Jun 5, 2012·International Journal of Radiation Oncology, Biology, Physics·Michael J EblanSmith Apisarnthanarax
Jun 9, 2012·International Journal of Radiation Oncology, Biology, Physics·David AlsadiusGunnar Steineck
Dec 19, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sylvie DelanianPierre-François Pradat

❮ Previous
Next ❯

Citations

Sep 16, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marc D Piroth
Aug 12, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Laurence LeysenNele Adriaenssens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Dan LundstedtPer Karlsson
Gan no rinsho. Japan journal of cancer clinics
Y KiharaK Shibata
© 2021 Meta ULC. All rights reserved