Radical cystectomy after bacillus Calmette-Guérin for high-risk Ta, T1, and carcinoma in situ: defining the risk of initial bladder preservation

Urology
Alan M NiederMark S Soloway

Abstract

To critically evaluate the survival of patients with high-grade Ta or T1 urothelial cancer (UC) or carcinoma in situ of the bladder who have received bacillus Calmette-Guérin (BCG) and who have undergone radical cystectomy. We retrospectively reviewed our single-surgeon database of those patients who underwent cystectomy and previously received BCG. We evaluated the baseline characteristics, pathologic outcomes, and survival data. Of 313 patients who underwent cystectomy between January 1992 and March 2004, 90 (29%) received BCG before bladder removal. The mean time from the first BCG course to the date of cystectomy was 27.9 months. The mean duration of follow-up from cystectomy was 32.1 months. The risk of progression to muscle invasion for those who underwent cystectomy less than or more than 1 year from the time of their first BCG dose was 59% and 36%, respectively (P = 0.05). The disease-specific survival rate was 81% versus 80% for those who underwent early versus delayed cystectomy (P = 0.9). Patients with high-grade UC are at risk of dying from this cancer, even if they ultimately undergo cystectomy. Patients who receive BCG should be appropriately counseled that they remain at risk for disease progression and death fro...Continue Reading

References

Jul 1, 1997·The Journal of Urology·M S CooksonW R Fair
Aug 23, 2000·The Journal of Urology·F Millán-RodríguezJ Vicente-Rodríguez
Jun 21, 2002·European Urology·Willem OosterlinckUNKNOWN European Association of Urology (EAU) Working Group on Oncological Urology
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Jan 10, 2006·Urology·Alan M NiederMichael A S Jewett

❮ Previous
Next ❯

Citations

Sep 23, 2014·Current Urology Reports·Matthew J PaganoJames M McKiernan
Aug 5, 2011·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Anil Mandhani
May 10, 2013·BMC Urology·Guy HidasOfer N Gofrit
Jun 1, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A Masson-LecomteL Salomon
Apr 2, 2013·The Urologic Clinics of North America·Siamak Daneshmand
Dec 1, 2007·Urologic Oncology·Eila C Skinner
May 23, 2008·BJU International·John P Stein, David F Penson
Mar 9, 2010·Expert Opinion on Pharmacotherapy·Steve K WilliamsMark Soloway
Jun 14, 2012·Postgraduate Medicine·Michael A GorinMark S Soloway
Dec 4, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Eiji KikuchiKazuhiro Matsumoto
Nov 13, 2010·BJU International·Mark S SolowayMurugesan Manoharan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.