Radical cystectomy in the treatment of bladder cancer: oncological outcome and survival predictors

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Chen-Hsun HoKuo-How Huang

Abstract

To better understand the result of radical cystectomy in the treatment of bladder cancer, we analyzed our data and reported the oncological outcomes and survival predictors. Patients underwent radical cystectomy for bladder transitional cell carcinoma between March 1995 and July 2007 were evaluated. The clinical course, pathological characteristics, and clinical outcomes were described and analyzed. A total of 148 patients (98 men and 50 women) with a median age of 66.7 years (range: 23.8-83.3) were included in the study. Median follow-up was 64 months. The perioperative mortality was 2.7%. The 5-year recurrence-free survival (RFS) and overall survival (OS) for all 148 patients was 61% and 53%, respectively. The 5-year RFS and OS were 68% and 62% for pT2, 65% and 59% for pT3, 11% and 9% for pT4, and 37% and 31% for nodal-positive disease, respectively. The number of positive lymph nodes was significantly associated with survival: 5-year RFS and OS were 54% and 33%, for patients with only 1-3 positive lymph nodes, whereas, all patients with >or= 4 positive lymph nodes had recurrence. On multivariate analysis, age > 60 years, pT4 tumors, and lymph node involvement had a negative impact on survival. Radical cystectomy can be curat...Continue Reading

References

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Citations

Jul 14, 2010·Future Oncology·Mohamed Saad Zaghloul
Sep 24, 2010·BJU International·Daniel LibermanPierre I Karakiewicz
Jun 19, 2015·Japanese Journal of Clinical Oncology·Rainy UmbasAgus Rizal A H Hamid
Nov 20, 2012·Journal of the Egyptian National Cancer Institute·Mohamed S Zaghloul
Jun 22, 2012·Expert Review of Anticancer Therapy·Mohamed S Zaghloul, Iman Gouda
Aug 4, 2010·Current Opinion in Urology

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