PMID: 8961364Oct 1, 1996Paper

Radical external beam radiotherapy for 333 squamous carcinomas of the oral cavity--evaluation of late morbidity and a watch policy for the clinically negative neck

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
S L TurnerR Swindell

Abstract

The aims of this study were to examine local control/morbidity for all cases and a 'watch policy' for the node-negative neck. 333 patients with squamous cell carcinoma of the oral cavity were treated with a short radical radiotherapy regime to the primary site and involved lymph node groups at the Christie Hospital, Manchester, between 1980 and 1987. Only 10 of 278 node-negative patients received elective neck node irradiation. Actuarial cancer-free survival and local control rates at 5 years for the whole group were 55% and 61%, respectively. Control at the primary site was adversely related to increasing T-stage, node positivity and bone involvement at presentation. Osteonecrosis was seen in 14 (5.9%) of 237 cases without bone involvement at presentation. Taking all patients, late morbidity (non-healing soft tissue injury or bone necrosis) was seen in 45 patients (13.6%) at a median time of 21 months from treatment. The factors contributing to late morbidity were: (1) bone involvement at presentation, (2) synchronous MTX chemotherapy, (3) the contribution of scattered radiation from elective neck treatment, (4) increasing radiation dose, (5) increasing target volume for doses less than 55 Gy and (6) dental extractions. Eighty...Continue Reading

Citations

Apr 15, 2010·The Journal of Laryngology and Otology·P SilvaJ J Homer
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·A J SykesA E Brewster
Jan 7, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J P WylieN J Slevin
Nov 5, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Clare P SchofieldNoor Z Z Rashid
Dec 8, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·N A BaymanN J Slevin
Apr 4, 2006·Otolaryngologic Clinics of North America·John P Campana, Arlen D Meyers
Nov 14, 2016·American Journal of Otolaryngology·Cameron C WickPierre Lavertu
Aug 5, 2008·Oral Oncology·Simon N RogersDavid Vaughan
Jul 9, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David PasquierEric Lartigau
Mar 23, 2006·Journal of Consulting and Clinical Psychology·Alina Morawska, Matthew R Sanders
Nov 8, 2008·Prevention Science : the Official Journal of the Society for Prevention Research·Andrew LacJason T Siegel
Jul 5, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerard Laden
Mar 11, 2004·The British Journal of Radiology·B K YapA Ahamad
Dec 19, 2012·Deutsches Ärzteblatt International·Klaus-Dietrich WolffAlexander Nast

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