Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

Angewandte Chemie
Jian RongJinbo Hu

Abstract

The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible-light photoredox catalysis. A wide range of readily available mono-, di-, and trifluoromethyl heteroaryl sulfones can thus be used as efficient radical fluoroalkylation reagents under mild conditions. This method not only describes a new synthetic application of fluorinated sulfones, but also provides a new route to fluoroalkyl radicals.

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Citations

May 18, 2016·The Journal of Organic Chemistry·Yang RanFeng-Ling Qing
Oct 26, 2016·Angewandte Chemie·Yajun Li, Fraser F Fleming
Nov 22, 2016·Chemical Society Reviews·Bingrui Song, Bin Xu
Oct 19, 2016·Organic & Biomolecular Chemistry·Hui ZhouRen Xiang Tan
Dec 22, 2017·Chemistry, an Asian Journal·Zhen-Yu WangXi-Sheng Wang
Sep 22, 2018·Organic & Biomolecular Chemistry·Ailada CharoenpolChutima Kuhakarn
Jan 27, 2019·ChemSusChem·He-Huan XuHai-Chao Xu
Mar 7, 2019·Angewandte Chemie·Min ZhangJi-Chang Xiao
Jun 4, 2020·Organic & Biomolecular Chemistry·Jun WeiJinbo Hu
Feb 6, 2020·Angewandte Chemie·Marco Reichel, Konstantin Karaghiosoff

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