Radical formation site of cerebral complex I and Parkinson's disease

Journal of Neuroscience Research
T FukushimaY Yamane

Abstract

Paraquat was reduced to the paraquat radical via complex I in bovine cerebral mitochondria and accelerated lipid peroxidation. Thirty-kilodalton subunit of complex I was considered to be the radical formation site, because of its marked destruction by the paraquat radical. The lipid peroxidation by the paraquat radical was suppressed not only by superoxide dismutase (SOD) but also by mannitol. The destruction of complex I subunits via lipid peroxidation must have been caused by the hydroxyl radical which was formed from the superoxide radical. The same phenomenon was observed by using 1-methylnicotinamide (MNA), which contains the same partial structure as paraquat in itself and is metabolized from nicotinamide in a living body. We observed NADH oxidation by MNA via cerebral complex I (Km = 26.3 mM), and MNA destroyed some complex I subunits, especially 30-kilodalton protein. Paraquat might be useful for studying the pathogenesis of Parkinson's disease (PD) in vitro, and MNA is expected to be one of the causal substances of PD from the viewpoint of the oxidative stress theory.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Feb 1, 1989·Trends in Neurosciences·C M Tanner
Sep 29, 1989·Biochemical and Biophysical Research Communications·Y MizunoY Kagawa
Dec 1, 1989·Annals of Neurology·W D ParkerJ K Parks
Dec 1, 1988·Biochemical Pharmacology·Z L RossettiN H Neff
Jan 1, 1985·Annual Review of Biochemistry·Y Hatefi
Feb 1, 1989·Journal of Neurochemistry·D T DexterC D Marsden
Apr 1, 1987·Neurology·J R Sanchez-RamosW J Weiner
Aug 1, 1986·Neurology·W C Koller
Nov 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A H RajputW Laverty
Jun 4, 1974·Biochemical and Biophysical Research Communications·J S BusJ E Gibson
Dec 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T FukushimaY Yamane
Aug 1, 1993·Biochemical Society Transactions·J M WilletsH R Griffiths
Oct 1, 1993·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T FukushimaY Yamane

❮ Previous
Next ❯

Citations

Jul 1, 2005·Environmental Health and Preventive Medicine·Akiko SugawaraTetsuhito Fukushima
Jan 18, 2012·Environmental Health and Preventive Medicine·Yayoi MoriTetsuhito Fukushima
Mar 29, 2007·The Journal of Biological Chemistry·Pablo R CastelloManisha Patel
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Mar 18, 2003·The Journal of Clinical Investigation·Jeffrey A Klein, Susan L Ackerman
Jan 1, 2005·Environmental Health and Preventive Medicine·Tetsuhito Fukushima
Jul 1, 2002·Environmental Health and Preventive Medicine·Tetsuhito FukushimaMasaki Moriyama
Apr 5, 2011·Parkinson's Disease·P C KeaneC M Morris
Feb 25, 2005·QJM : Monthly Journal of the Association of Physicians·A C WilliamsD B Ramsden
Oct 1, 2013·Nature Chemical Biology·Kathrin SchmeisserMichael Ristow
Oct 22, 2013·Nature Chemical Biology·Heinrich Jasper
Feb 24, 2016·Scientific Reports·Pamela FarshimAlexis Bailey
Aug 4, 2004·Toxicology and Applied Pharmacology·Leonard W VelsorBrian J Day
Jan 11, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Adrian C Williams, David B Ramsden
Apr 3, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Tetsuhito FukushimaMasaki Moriyama
Jul 1, 2008·Environmental Toxicology and Pharmacology·A Mohammadi-Bardbori, M Ghazi-Khansari
Mar 9, 2010·Toxicology and Industrial Health·Ibrahim Abdulwahid Arif, Haseeb Ahmad Khan
Dec 18, 2001·Journal of Applied Toxicology : JAT·A KaetsuM Moriyama
May 20, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Samuel M GoldmanCaroline M Tanner
Jul 28, 2020·Ageing Research Reviews·Hamid Reza NejabatiMohammad Nouri
Apr 16, 1998·Biochemical and Biophysical Research Communications·R Hegde

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Tetsuhito FukushimaMasaki Moriyama
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
T F Moriyama
© 2021 Meta ULC. All rights reserved