PMID: 9422570Jan 9, 1998Paper

Radical prostatectomy and postoperative irradiation in patients with pathological stage C (T3) carcinoma of the prostate

International Journal of Radiation Oncology, Biology, Physics
Z PetrovichD G Skinner

Abstract

Adenocarcinoma of the prostate is the most common human cancer of internal organs. Radical surgery is regarded by many to be the treatment of choice for capsule confined disease. Since accurate preoperative assessment of tumor stage is difficult to define, many patients are subsequently found to have pathological stage C (T3) disease. These patients should be considered for adjuvant radiotherapy. A group of 201 PS C (T3) unselected patients, treated with radical prostatectomy and limited pelvic lymphadenectomy, received postoperative irradiation to the prostate bed. This radiotherapy was given between 42-90 days after surgery and consisted of a median dose of 48 Gy. Patient survival, disease free survival, time to clinical and chemical relapse and the incidence of local and systemic relapse were analyzed. The influence of multiple parameters on the treatment outcome including patient age, treatment period, clinical stage, pathological stage, Gleason's score, prostate specific antigen (PSA), radiotherapy techniques and radiation dose were examined using univariate and multivariate analysis. Follow-up ranged from 3 to 15 years, with a median of 5 years. The overall 5- and 10-year actuarial survival was 92% and 83% (median > 10 ye...Continue Reading

References

Sep 1, 1991·International Journal of Radiation Oncology, Biology, Physics·Z PetrovichD G Skinner
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·B E ShevlinR M Shetty
Feb 1, 1994·Urology·J E Johansson
Jan 27, 1994·The New England Journal of Medicine·G W ChodakJ Warner
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·S E SchildR G Ferrigni

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Citations

Jun 29, 2000·Medical Oncology·S N PentyalaS A Khan
May 21, 2003·Current Urology Reports·John F Ward, Horst Zincke
Apr 11, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C CattonM Milosevic
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Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H Van PoppelE Chirpaz
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May 18, 1999·Current Opinion in Oncology·E J Small
May 15, 2003·Scandinavian Journal of Urology and Nephrology·Bo LennernäsSten Nilsson

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