PMID: 9436288Jan 1, 1997Paper

Radical prostatectomy as treatment for prostate-specific antigen-detected stage T1c prostate cancer

World Journal of Urology
C R PoundA W Partin

Abstract

The use of serum prostate-specific antigen (PSA) measurement as a method for early detection of prostate cancer has increased the detection of clinically and pathologically localized prostate cancer. Clinical stage T1c was introduced to describe cancers discovered on prostate biopsy as a result of an abnormal serum PSA level without a palpable prostatic abnormality on digital rectal examination. The majority of men with stage T1c tumors have significant disease warranting treatment. We report the results of anatomic radical retropubic prostatectomy as therapy for PSA-detected stage T1c prostate cancer in 340 men treated at a single institution. In all, 17 men (5%) have had a recurrence with 2.3 +/- 1.2 years of follow-up, 15 of whom have experienced an isolated biochemical PSA recurrence only. The overall actuarial biochemical PSA recurrence-free rate at 6 years is 87%, with pathologic stage being the best single indicator of the likelihood of progression. Although a longer period of follow-up is needed, this interim report suggests that these men can be cured by surgery at rates equal to or better than those of previously reported radical prostatectomy series.

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Citations

Jun 29, 2000·Medical Oncology·S N PentyalaS A Khan
Dec 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F M Debruyne, H P Beerlage
Aug 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S LoricP Eschwège
Apr 12, 2003·The Lancet Oncology·Richard E Peschel, John W Colberg
Mar 10, 2011·BMC Medical Informatics and Decision Making·Hsueh-Chun LinJong-Yi Wang Wang
Apr 15, 2014·The Urologic Clinics of North America·Richard J Bryant, Hans Lilja
Oct 10, 2001·The Urologic Clinics of North America·R E Link, R A Morton
Dec 29, 2012·Journal of the National Cancer Institute. Monographs·William M HiltonIan M Thompson
Apr 15, 2003·Oncology Nursing Forum·LouAnn M Rondorf-Klym, Joyce Colling

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