Radical prostatectomy for locally advanced prostate cancer: results of a feasibility study (EORTC 30001)

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Hein Van PoppelLaurence Collette

Abstract

The aim of this open, non-randomised, 2-stage feasibility study was to determine whether radical prostatectomy (RP) was safe and could provide cure for good prognosis patients with clinical T3 prostate cancer, in a multicentre setting. Cure was defined as a 3 months post-operative of undetectable serum PSA in combination with the presence of pathologically negative margins in the surgical specimen. Forty patients were enrolled of whom 38 were eligible. Six patients (5 pN+ and 1 pNx) did not meet the inclusion criteria and were excluded leaving 32 evaluable pN0 patients of whom 19 (59.4%, SE=4.26) achieved a complete response (CR) and in whom only two serious toxic events (STEs) were observed. The results of the first phase of the study passed the toxicity criteria (<3 STE's) but failed on the cure rate (>20 CRs). This resulted in discontinuation of the study after the first stage. The main reason for failure was the incidence of positive margins in the resected specimen. Although the study was stopped after the first phase, 28 of the 32 pN0 patients (87.5%) had undetectable serum PSA at 3 months. We continue to believe that RP with extensive resection can be beneficial as monotherapy for T3aN0M0 prostate cancer.

References

Jan 1, 1997·Virchows Archiv : an International Journal of Pathology·D G Bostwick, R Montironi
Apr 21, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H Van PoppelUNKNOWN EORTC GU Group
May 11, 2002·Scandinavian Journal of Urology and Nephrology·G AusA Widmark
Jan 1, 1998·Urologic Oncology·D HodgsonM Gospodarowicz

❮ Previous
Next ❯

Citations

Sep 30, 2008·Der Urologe. Ausg. A·R-J Palisaar, J Noldus
Sep 17, 2010·Der Urologe. Ausg. A·A Heidenreich, A J Schrader
Sep 4, 2008·Current Urology Reports·Ofer Yossepowitch, James A Eastham
Mar 12, 2011·Nature Reviews. Urology·Sheng Fei OonR William G Watson
Nov 23, 2010·Journal of Endourology·Jason D EngelY Mark Hong
Dec 7, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·L SalomonUNKNOWN Oncology Committee of the French Association of Urology (CCAFU)
May 18, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A CarcenacC Bastide
Feb 9, 2012·Current Urology Reports·Alexandre IngelsGuillaume Ploussard
Jul 24, 2013·Expert Review of Anticancer Therapy·François RozetXavier Cathelineau
May 27, 2011·Critical Reviews in Oncology/hematology·Lars BudäusUNKNOWN Association of Radiotherapy and Oncology of the Mediterranean arEa (AROME)
Apr 29, 2009·Surgical Oncology·Charlotte L Foley, Mark R Feneley
Apr 28, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·E XylinasM Rouprêt
Oct 24, 2007·European Urology·Hendrik Van Poppel, Steven Joniau
Dec 19, 2006·European Urology·Andrea GallinaPierre I Karakiewicz
Jan 16, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Felix K-H ChunPierre I Karakiewicz
Aug 12, 2009·BJU International·Kelly L Stratton, Sam S Chang
Nov 15, 2008·BJU International·Rodolfo MontironiAntonio Lopez-Beltran
Feb 9, 2012·BJU International·Marco OderdaPaolo Gontero
Jun 7, 2015·Urology·Eliney F FariaSurena F Matin
Apr 15, 2008·Urology·Hendrik van Poppel, Sten Nilsson
Nov 7, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J-B RocheP Rischmann
Feb 25, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Mohsen BeheshtiWerner Langsteger
May 27, 2017·Indian Journal of Surgical Oncology·N SrivatsaS K Raghunath
Nov 12, 2020·Nature Reviews. Urology·Lamont J WilkinsYaw A Nyame
Nov 1, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ryogo MinamimotoAndrei Iagaru
Mar 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias EiberMarkus Schwaiger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.