Radical prostatectomy in very high-risk localized prostate cancer: long-term outcomes and outcome predictors

Scandinavian Journal of Urology and Nephrology
Steven JoniauHein Van Poppel

Abstract

The objective of this study was to present the long-term outcomes and determine outcome predictors in very high-risk (cT3b-T4) prostate cancer (PCa) after radical prostatectomy (RP). Between January 1989 and December 2004, 51 patients with cT3b-T4 PCa underwent RP. Kaplan-Meier survival analysis was used to calculate the biochemical progression-free survival (BPFS), clinical progression-free survival (CPFS), cancer-specific survival (CSS) and overall survival (OS) rate. Multivariate Cox proportional hazard models were used to determine the predictive power of clinical and pathological variables in BPFS and CPFS. Median follow-up was 108 months [interquartile range (IQR) 73.5-144.5]. The median serum prostate-specific antigen (PSA) was 16.9 ng/ml (IQR 7-37.2). Median biopsy and pathological Gleason (pGS) score were both scored as 7 (range 4-10 and 5-9, respectively). Overstaging was frequent (37.2%); four patients (7.8%) had organ-confined stage pT2, while 15 (29.4%) had extracapsular extension only (pT3a). Another 23 (45.1%) were confirmed with seminal vesicle invasion (pT3b) and nine (17.7%) had adjacent structure invasion (pT4). Eleven patients (21.6%) had lymph-node involvement. Thirty-two patients (62.7%) had positive surgi...Continue Reading

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Citations

Jan 12, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Joseph Ischia, Martin Gleave
May 9, 2016·Critical Reviews in Oncology/hematology·Alessandro Morlacco, R Jeffrey Karnes
Feb 13, 2014·American Journal of Clinical Oncology·Mark ShilkrutDaniel A Hamstra
May 24, 2013·Korean journal of urology·Hee Ju ChoTag Keun Yoo
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Nov 12, 2020·Nature Reviews. Urology·Lamont J WilkinsYaw A Nyame

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