PMID: 2105910Feb 1, 1990Paper

Radical scavengers of indapamide in prostacyclin synthesis in rat smooth muscle cell

Hypertension
Y UeharaT Sugimoto

Abstract

Indapamide, a nonthiazide diuretic, exhibits direct vasodilator action as well as natriuretic and diuretic effects. Although calcium antagonist-like activity has been addressed so far, the mechanisms for vasodilator effect are still uncertain. To understand the wide range of indapamide actions, we examined the effects of indapamide on the vascular eicosanoid generation and investigated its mechanisms by using rat vascular smooth muscle cells in culture. Indapamide uniquely increased the prostacyclin generation in the vascular smooth muscle cells in a dose-dependent manner, whereas it did not affect the vasoconstrictor thromboxane A2. Thiazide diuretics lowered the prostacyclin generation, while nonthiazide derivatives did not affect the biosynthesis. Enzymatic analysis revealed that indapamide affected neither [14C]arachidonate liberation nor prostacyclin synthase of the smooth muscle cells. Indapamide eliminated a stable free radical in a cell-free system, lowered the formation of malondialdehyde from lipid peroxides in rat brain homogenate, and reduced lipid peroxidation by the free radical generating system of xanthine-xanthine oxidase. Indeed, the scavenging action of indapamide significantly attenuated the inhibitory activ...Continue Reading

References

Jan 1, 1977·Current Medical Research and Opinion·J WoodlandB Vernon-Roberts
Dec 1, 1979·Prostaglandins·O V MillerR R Gorman
Feb 15, 1988·Experientia·F R Bühler, T J Resink
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·L J Ignarro, P J Kadowitz
Dec 1, 1986·Circulation Research·R C KukrejaE F Ellis
Jan 29, 1988·The American Journal of Medicine·B Delbarre, G Delbarre
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R RossL Harker
Feb 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·N Kageyama
Mar 1, 1982·Archives of Biochemistry and Biophysics·M W Sutherland, J M Gebicki
Jul 1, 1983·American Heart Journal·J H Morledge
Jan 1, 1982·Methods in Enzymology·J A Salmon, R J Flower
Nov 1, 1982·Hypertension·O KuchelJ Genest

❮ Previous
Next ❯

Citations

Jun 28, 2005·Clinical and Experimental Nephrology·Misa TanakaTakahiko Ono
Jun 20, 1998·Biochemical Pharmacology·G ChenT D Warner
Jan 10, 2002·European Journal of Pharmacology·P GanadoT Tejerina
Aug 6, 2009·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Stanislava VrankováOlga Pechanova
Nov 30, 2005·Fundamental & Clinical Pharmacology·J SassardH McIntyre
May 2, 1990·The American Journal of Cardiology·D B Campbell, F Brackman
Mar 5, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Hirotsugu YamadaMasataka Sata
Feb 1, 1995·Hypertension·A BenetosM E Safar
Oct 14, 2016·Terapevticheskiĭ arkhiv·A A SemenkinT V Pritykina
Jun 9, 2010·The Annals of Otology, Rhinology, and Laryngology·Cahtia AdelmanHaim Sohmer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.