Radical surgery after chemotherapy: a new therapeutic strategy to envision in grade II glioma.

Journal of Neuro-oncology
Hugues DuffauL Capelle

Abstract

While surgery is proned in low-grade glioma (LGG), the invasion of functional areas frequently prevents a complete resection. We report the first case of a patient operated on for a left frontal LGG, diagnosed because of seizures, with partial resection due to an invasion of the controlateral hemisphere. Chemotherapy enabled a regression of this controlateral extension. Postchemotherapy surgery performed with intraoperative functional mapping then allowed a complete resection, without sequelae. The patient has a normal socio-professional life, with no seizure. No other treatment was given. There was no recurrence, with a follow-up of 2 years since the second surgery (3.5 years since the first symptom). We propose a new therapeutic strategy in unresectable LGG, with preoperative chemotherapy, to make a radical surgery possible in a second step, while preserving the quality of life.

References

Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherH D Bear
Nov 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S FriedmanS C Schold
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer A QuinnHenry S Friedman
May 29, 2003·The Journal of Urology·Ashraf A MosharafaJohn P Donohue
Jul 10, 2003·Lancet Neurology·Peter H WesselsAlbert Twijnstra
Nov 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A PaceC M Carapella
Feb 7, 2004·Seminars in Oncology·Rolf-Dieter Kortmann
Jun 16, 2004·Cancer·Hugues Duffau, Laurent Capelle
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K Hoang-XuanJ Y Delattre
Apr 7, 2005·The Lancet Oncology·Michael A PapagikosVolker W Stieber
Jul 29, 2005·Annals of Neurology·Michèle KujasJean-Yves Delattre

❮ Previous
Next ❯

Citations

Jun 9, 2015·Journal of Neurosurgery·Gentian KaloshiMentor Petrela
Apr 29, 2010·Current Neurology and Neuroscience Reports·Nader Pouratian, David Schiff
Feb 25, 2011·Neurosurgery·Alessandro De Benedictis, Hugues Duffau
Aug 20, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R SoffiettiW Wick
Nov 6, 2007·Nature Clinical Practice. Neurology·Nader PouratianDavid Schiff
Jul 17, 2009·Current Opinion in Oncology·Hugues Duffau
Nov 3, 2020·World Neurosurgery·Javier A JacoboSergio Moreno-Jimenez
Sep 12, 2014·Journal of Medicinal Chemistry·Ludovic ClarionNorbert Bakalara
Jul 24, 2012·Clinical Neurology and Neurosurgery·Christina Louise Pedersen, Bertil Romner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.