Radio-contrast agent-induced hyperthyroidism: case report and review of the literature

Archives of Endocrinology and Metabolism
Ioannis IakovouDimitrios G Goulis

Abstract

A 66 year-old woman with a history of a euthyroid multinodular goiter underwent a head and neck computed tomography (CT) scan (total iodine load of 35 g) in order to evaluate the extent of retrosternal expansion. Less than 24 h after the iodine-based contrast media (ICM) administration, she presented with symptoms and laboratory findings typical of thyrotoxicosis. She was treated successfully with antithyroid medications. This is the shortest time reported in the literature and it is of clinical importance, as it may have an impact to the recommendations given by the attending physician. Given the fact that a large number of ICM examinations are performed in everyday practice, physicians should be aware of this possible thyroid-specific effect. Prophylactic drugs could be considered in high-risk populations, such as administration of perchlorate and a thionamide class drug to elderly patients with suppressed TSH and/or palpable goiter, started the day before and continued for two weeks after ICM administration.

References

Aug 17, 2004·Thyroid : Official Journal of the American Thyroid Association·Wolfgang Gartner, Michael Weissel
Jan 25, 2012·Archives of Internal Medicine·Connie M RheeSteven M Brunelli
Jul 24, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Angela M Leung, Lewis E Braverman
Nov 29, 2013·Clinical Endocrinology·Bartosz Hudzik, Barbara Zubelewicz-Szkodzińska
Jun 5, 2014·BioMed Research International·Michele AndreucciAdis Tasanarong

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Citations

Feb 22, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Rohan K Henry, Monika Chaudhari

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