Radio fluorination and positron emission tomography (PET) as a new approach to study the in vivo distribution and elimination of the advanced glycation endproducts N epsilon-carboxymethyllysine (CML) and N epsilon-carboxyethyllysine (CEL)

Die Nahrung
R BergmannThomas Henle

Abstract

After synthesis of fluorine-18 labelled analogues by [18F]fluorobenzoylation at the alpha-amino group, biodistribution and elimination of individual advanced glycation endproducts, namely N epsilon-carboxymethyllysine and N epsilon-carboxyethyllysine, were studied in comparison to lysine in rats after intravenous injection using positron emission tomography (PET). The [18F]radiofluorinated amino acids were fast distributed via the blood, followed by a rapid excretion through the kidneys. Elimination kinetics were similar for both AGEs and lysine. For CML and CEL, but not for lysine, a temporary liver accumulation could be observed, which was not connected with any metabolisation or enterohepatic circulation. No further accumulation in any tissues was observable, indicating that increased tissue levels of CML or CEL, which have been described for certain disorders, are exclusively derived from endogenous origin and should not depend on a dietary intake. However, under uremic conditions, an impaired kidney function might result in a significant increase of the AGE-load of blood and tissues. PET based on 18F-labelled AGEs proved to be a promising tool to elucidate the physiological fate of post-translationally modified amino acids...Continue Reading

Citations

Oct 16, 2010·Amino Acids·Francisco J MoralesVincenzo Fogliano
Oct 19, 2010·Amino Acids·Monika Pischetsrieder, Thomas Henle
Oct 16, 2010·Amino Acids·Frédéric J Tessier, Inès Birlouez-Aragon
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Malene W PoulsenLars O Dragsted
Apr 9, 2009·Transplantation·Jasper W L HartogStephan J L Bakker
Oct 12, 2013·International Journal of Food Sciences and Nutrition·Norbert NassAndreas Simm
Oct 16, 2015·Food & Function·Cristina Delgado-Andrade
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katarína SebekováAugust Heidland
Jun 1, 2005·Molecular Nutrition & Food Research·Veronika Somoza
Mar 6, 2008·Molecular Nutrition & Food Research·Timo M BuetlerThierry Delatour
Sep 15, 2007·Molecular Nutrition & Food Research·Jennifer M Ames
Aug 19, 2006·Molecular Nutrition & Food Research·Veronika SomozaHelmut F Erbersdobler
Mar 16, 2007·Molecular Nutrition & Food Research·Iliyana D StefanovaAthanas D Krustev
Aug 21, 2010·Molecular Nutrition & Food Research·Martinus van BoekelGerhard Eisenbrand
Sep 2, 2004·The Journal of Laboratory and Clinical Medicine·Reinald Pamplona, Manuel Portero-Otin
Sep 18, 2015·Nutrition Reviews·Nicole J Kellow, Melinda T Coughlan
Oct 19, 2006·Nuclear Medicine and Biology·Christina HultschThomas Henle
Jan 27, 2016·Journal of Animal Science·C van RooijenW H Hendriks
Nov 26, 2019·Critical Reviews in Food Science and Nutrition·Zhili LiangZhao Yang
Sep 30, 2020·Glycoconjugate Journal·Frederic J TessierMichael Howsam
Nov 26, 2015·Journal of Food Science and Technology·Chetan SharmaShiveta Raina

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