Radio-immuno binding test for anti-sperm antibody detection: analysis and critical revision of various methodological steps

Andrologia
L GandiniF Dondero

Abstract

The authors report the results of a methodological study to optimize a radioimmunoassay to detect anti-sperm antibodies. They describe here the definitive methodology with all the data relating to the laboratory trials conducted at each step of the technique. Results seem to demonstrate that this radioimmunological method is sufficiently simple, specific, sensitive and reliable for use in a highly specialized laboratory of reproductive immunology. Furthermore, this type of analytical approach, whilst indicating once more the difficulty of the technical study of anti-sperm autoimmunity, confirms (with concrete data) the necessity of being extremely "prudent" in evaluating the results of this kind of anti-sperm antibody test.

References

Oct 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·G N Clarke
Apr 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·G N ClarkeW I Johnston
Jan 1, 1972·Journal of Reproduction and Fertility·R P Erickson
Jan 1, 1969·Fertility and Sterility·R W Noyes
Mar 1, 1980·Fertility and Sterility·L A Hill, J K Hampton
Jul 1, 1982·Fertility and Sterility·G G HaasD P Wolf
Dec 1, 1981·Fertility and Sterility·R BronsonD Rosenfeld
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Citations

Jun 1, 1995·Journal of Endocrinological Investigation·A Lenzi
Nov 5, 1997·American Journal of Reproductive Immunology : AJRI·F DonderoA Lenzi

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