Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice.

Science
Sarah A StanleyJeffrey M Friedman

Abstract

Medical applications of nanotechnology typically focus on drug delivery and biosensors. Here, we combine nanotechnology and bioengineering to demonstrate that nanoparticles can be used to remotely regulate protein production in vivo. We decorated a modified temperature-sensitive channel, TRPV1, with antibody-coated iron oxide nanoparticles that are heated in a low-frequency magnetic field. When local temperature rises, TRPV1 gates calcium to stimulate synthesis and release of bioengineered insulin driven by a Ca(2+)-sensitive promoter. Studying tumor xenografts expressing the bioengineered insulin gene, we show that exposure to radio waves stimulates insulin release from the tumors and lowers blood glucose in mice. We further show that cells can be engineered to synthesize genetically encoded ferritin nanoparticles and inducibly release insulin. These approaches provide a platform for using nanotechnology to activate cells.

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Feb 1, 1984·IEEE Transactions on Bio-medical Engineering·P R StaufferR C Jones
Sep 30, 1999·Microscopy Research and Technique·G E Hardingham, H Bading
May 25, 2002·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Y Rabin
Oct 5, 2002·Journal of Neurophysiology·Cameron C McIntyre, Warren M Grill
Apr 1, 1954·Biochimica Et Biophysica Acta·J L FARRANT
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert G Thorne, Charles Nicholson
Feb 3, 2007·Journal of the American Chemical Society·Jean-Paul FortinFlorence Gazeau
Sep 27, 1940·Science·E GellhornJ Feldman
Jul 11, 2008·Expert Opinion on Biological Therapy·Andrew Z WangOmid C Farokhzad
Nov 11, 2008·Biochemistry·Christopher A ButtsIvan J Dmochowski
Dec 18, 2008·Nature Immunology·Anjana Rao
Jan 6, 2009·Journal of Materials Chemistry·Bappaditya SamantaVincent M Rotello
Oct 24, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A JordanR Felix
Apr 20, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Bistra IordanovaEric T Ahrens
Dec 22, 2010·Biointerphases·Barindra SanaSierin Lim
Jul 29, 2011·Nanotechnology·A J GiustiniP J Hoopes
Dec 14, 2011·The New England Journal of Medicine·Amit C NathwaniAndrew M Davidoff

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Citations

Oct 26, 2013·Nano Today·Chang Soo KimVincent M Rotello
Sep 1, 2012·Journal of the American Chemical Society·Samuel E Lohse, Catherine J Murphy
May 16, 2013·Journal of the American Chemical Society·Juan LiuKevin M Rosso
Sep 20, 2012·ACS Nano·Leslie D KnechtSylvia Daunert
Dec 15, 2012·ACS Nano·Matthew D BlankschienMichael S Wong
Mar 22, 2013·ACS Nano·A Paul AlivisatosXiaowei Zhuang
Jun 21, 2013·Nature Materials·Philip Ball
Aug 10, 2012·Nature Methods·Daniel Evanko
Jan 17, 2013·Physical Chemistry Chemical Physics : PCCP·Adrian PorchPeter P Edwards
Mar 22, 2013·Science Translational Medicine·Brian Y Chow, Edward S Boyden
Jul 31, 2013·Molekuliarnaia biologiia·A V BruterA V Beliavskiĭ
May 7, 2013·Annual Review of Biomedical Engineering·Gang BaoSheng Tong
Aug 29, 2012·PloS One·Bradley Michael ZamftGeorge Church
Oct 23, 2013·ACS Synthetic Biology·Masaki YamaguchiMasamichi Kamihira
Dec 4, 2013·Annals of Biomedical Engineering·Sheng TongGang Bao
Oct 29, 2013·Annual Review of Pharmacology and Toxicology·Boon Chin HengMartin Fussenegger
Aug 28, 2012·Biotechnology Advances·Hui ChenYanan Du
May 17, 2014·Current Opinion in Biotechnology·Sarah Stanley
Jul 12, 2014·Annual Review of Biomedical Engineering·B ShapiroD A Depireux
Nov 12, 2014·Nature Communications·Marc FolcherMartin Fussenegger
May 23, 2014·FEBS Letters·Haifeng Ye, Martin Fussenegger
Feb 5, 2013·FEBS Letters·Yuri Matsumoto, Alan Jasanoff
Jan 13, 2016·Nano Letters·Ritchie ChenPolina Anikeeva
Jan 5, 2016·Cell Metabolism·Scott M SternsonShengjin Xu
Aug 26, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yue LuZhen Gu
Feb 14, 2015·Current Opinion in Biotechnology·Boon Chin HengMartin Fussenegger
Jul 18, 2014·Nucleic Acids Research·Mingqi XieMartin Fussenegger
Feb 19, 2013·Current Opinion in Biotechnology·Yoram Cohen, Shani Yariv Shoushan
Dec 19, 2012·Trends in Biotechnology·Simon Ausländer, Martin Fussenegger
Dec 25, 2012·Colloids and Surfaces. B, Biointerfaces·Ruixia HouJun Fu
Oct 6, 2012·Journal of Biotechnology·Taeuk KimMartin Fussenegger
Nov 26, 2015·Chemistry : a European Journal·Yuanyuan CaoYapei Wang
Feb 18, 2016·Neural Plasticity·R Ramírez-BarrantesP Olivero
Jan 23, 2015·ACS Nano·Maksym V KovalenkoWolfgang Heiss
Aug 8, 2014·Molecular Pharmaceutics·Zhanar AbilHuimin Zhao
Oct 10, 2015·Cell
Mar 8, 2016·Nature Neuroscience·Michael A WheelerAli D Güler

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