Radioactive iodine therapy: effect on functioning metastases of adenocarcinoma of the thyroid

CA: a Cancer Journal for Clinicians
S M SeidlinE Oshry

Abstract

A case of metastatic adenocarcinoma of the thyroid is reported in which treatment by means of radioactive iodine has been successful. The patient was completely thyroidectomized for "malignant adenoma" in 1923, with neither thyrotoxicosis then nor hypothyroidism postoperatively; 15 years later there developed classic symptoms of hyperthyroidism and severe pain in the lower back. In October 1939 a pulsating tumor removed from the level of the 12th thoracic vertebra proved to be metastatic thyroid adenocarcinoma (histologically well differentiated, with small follicles and colloid). In the next two years hyperthyroidism increased and roentgenograms revealed new metastases in the lungs, upper part of the right femur, second rib on the left side, left ilium, and skull. Roentgenologic irradiation of the metastases proved ineffectual. In March 1943 a tracer dose of radioactive iodine revealed iodine retention by all the known lesions and no evidence of residual thyroid tissue in the neck. Therapeutic amounts of radioactive iodine were administered orally between May and October 1943. Definite and lasting clinical improvement followed. In April 1944 and March 1945 additional I* was administered with a resultant disappearance of pain, ...Continue Reading

Citations

Jan 6, 2016·International Journal of Molecular Sciences·Sergey V GudkovAndrei V Zvyagin
Oct 17, 1998·The Journal of Laryngology and Otology·A C SeeC Fisher
Jan 13, 2006·Thyroid : Official Journal of the American Thyroid Association·Gavin C Mackie, Barry L Shulkin
Nov 11, 2010·Thyroid : Official Journal of the American Thyroid Association·Wendy SacksGlenn D Braunstein
May 15, 2007·The British Journal of Radiology·M HaqC Harmer
Oct 21, 2010·Cancer Research·Matilde TodaroGiorgio Stassi
Apr 27, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Mahdi HaghighatafsharTahereh Ghaedian

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