PMID: 8946017Nov 4, 1996Paper

Radioadaptation for gene mutation and the possible molecular mechanisms of the adaptive response

Mutation Research
O Rigaud, E Moustacchi

Abstract

This paper reviews the experimental results showing that a prior exposure to a low dose of ionising radiation induces an adaptive response expressed as a reduction of gene mutation in various cell systems. The data show that the mutagenic adaptation shares common features with the clastogenic adaptation, i.e., priming dose level, kinds of conditioning agents, time interval between conditioning and challenging treatments, degree of induced protective effect (40-75%), transitory response and inhibition by 3-aminobenzamide, a DNA repair inhibitor. Moreover, the deletion-type mutations are predominantly reduced in adapted cells, suggesting that the mechanism underlying mutagenic adaptation preferentially facilitates the removal of the DNA lesions leading to deletion-type mutations. These lesions are thought to be double-strand breaks which are likely to be also involved in the production of chromosomal damage. Recent findings on the molecular processes implicated in the cellular response to radiation provide some clues for the mechanisms that could be triggered by low-dose exposure and ultimately contribute to the protective effect. There is some evidence that the protein kinase C-mediated signalling pathway is a key step for the t...Continue Reading

References

Feb 1, 1992·Mutation Research·J D Shadley, G Q Dai
Nov 1, 1991·Mutation Research·S Z Aghamohammadi, J R Savage
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A BoothmanS W Lee

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Citations

Aug 3, 2004·Journal of Biosciences·Ashu Bhan Tiku, R K Kale
Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A TakahashiT Ohnishi
Apr 24, 1999·Biochimie·F Eckardt-Schupp, C Klaus
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·M C JoinerI Turesson
Apr 10, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·M C JoinerB Marples
Nov 24, 2001·Mutation Research·Kamila Schlade-BartusiakMaria Sasiadek
Aug 6, 2002·Mutation Research·Karen J SorensenJames D Tucker
Jan 14, 2000·Mutation Research·E Moustacchi
Oct 25, 2011·Photochemistry and Photobiology·Patricia CramersAlbert A van Zeeland
Oct 4, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Morio Yonezawa
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Shu-Zheng Liu
Mar 1, 2012·Molecular Biology Reports·M Ahmad ChaudhryEdouard I Azzam
Sep 30, 2004·Radiation and Environmental Biophysics·Moshe SchafferEckhart Dühmke
Feb 10, 2006·Radiation and Environmental Biophysics·M TubianaR Masse
Feb 12, 2009·International Journal of Radiation Biology·G VaresI Hayata
Mar 24, 2010·Mutation Research·Dexiao YuanChunlin Shao
Oct 9, 2007·Mutation Research·Fumio YatagaiFumio Hanaoka
Aug 24, 2006·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·M TubianaR Masse
Dec 21, 2007·Environmental and Molecular Mutagenesis·Michael KilemadeDouglas Boreham
Sep 14, 2004·International Journal of Radiation Biology·S A MitchellE J Hall
Sep 30, 2008·International Journal of Radiation Biology·Ari MarkkanenJonne Naarala
Jul 8, 2009·Radiation Research·Anna SanninoMaria Rosaria Scarfì
Aug 15, 2009·Journal of Radiation Research·Fumio YatagaiMasamitsu Honma
Dec 12, 2018·Cellular and Molecular Life Sciences : CMLS·Yann GuéguenTeni G Ebrahimian
Jun 12, 2002·Journal of Radiation Research·Akihisa Takahashi
Apr 12, 2006·Molecular and Cellular Biochemistry·Rakesh Kumar Singh, Malini Krishna
Dec 1, 2020·ELife·Nathanaëlle SaclierChristophe J Douady
Dec 12, 2020·Electromagnetic Biology and Medicine·Mahsa MansourianZuhair Mohammad Hassan

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