PMID: 7523880Oct 1, 1994Paper

Radioadaptive response in primary mouse spermatocytes revealed by analysis of synaptonemal complexes

Mutation Research
P M BorodinH Yamamura

Abstract

This study was aimed at estimating the damage to the synaptonemal complex (SC) of male mice caused by radiation exposure at the ultimate pre-meiotic interphase. Four experimental groups were formed: group 1 was an untreated control, group 2 received a low dose (50 mGy) of radiation, group 3 a high dose (4 Gy) of radiation, group 4 was first treated with a low dose (50 mGy) and 4 h later with a high dose (4 Gy). Mice were killed 4 days after the treatment. Early pachytene cells were selected for the electron microscopic analysis of SCs. These cells were supposed to be at pre-meiotic interphase at the time of irradiation. Treatment with a low dose of radiation did not produce any substantial increase in the frequency of SC aberrations, while exposure to the high dose resulted in various types of damage. Group 4 demonstrated significantly lower frequencies of axial breaks/fragments and multiaxial configurations than group 3. At the same time, these two groups did not differ in the frequencies of inter- and intrachromosomal exchanges such as translocations, inversions, and deletions. We suppose that the number of breaks produced by a high dose of radiation was the same in the both groups. However, a proportion of the breaks that re...Continue Reading

References

May 19, 1977·Nature·L Samson, J Cairns
Jan 1, 1970·Chromosoma·S Kofman-Alfaro, A C Chandley

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