Radiobiological compensation of treatment errors in radiotherapy

The British Journal of Radiology
B Jones, R G Dale

Abstract

The linear quadratic model of radiation effect and the biologically effective dose concept can sometimes be used to provide radiobiological compensation for errors that have occurred in radiotherapy dose delivery. The associated mathematics is not complex, but there are important subtleties, which can lead to misunderstanding and erroneous corrections if the processes involved are not properly understood. Unfortunately, training in this area is, at best, patchy. In this article, several worked examples are used to demonstrate the principles involved in establishing error compensations, including cases in which dose distribution is itself changed as a result of the error. Compromise solutions are sometimes necessary, and close liaison between the clinician, physicist and (where possible) radiobiologist is necessary to obtain the best (and safest) compensation.

References

Oct 15, 1995·International Journal of Radiation Oncology, Biology, Physics·H R WithersN Gupta
May 26, 2001·Clinical Oncology : a Journal of the Royal College of Radiologists·B JonesD A Morgan
Jan 31, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·R G DaleJ A Sinclair
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jack F FowlerJosé H Leborgne
Feb 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Bleddyn JonesAndrew M Gaya
Feb 10, 2007·BMJ : British Medical Journal·Liam Donaldson
Feb 20, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·M V Williams
Feb 20, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·W P M Mayles

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Citations

Jul 7, 2010·The British Journal of Radiology·J F Fowler
Oct 6, 2012·Cancer Control : Journal of the Moffitt Cancer Center·Tuya Pal, Susan T Vadaparampil

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